- Aromatic-ring-containing compound, preparation method thereof, pharmaceutical composition and application thereof
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The invention discloses an aromatic-ring-containing compound, a preparation method thereof, a pharmaceutical composition and application. The present invention provides the aromatic-ring-containing compound represented by a formula 1, a pharmaceutically acceptable salt thereof, a stereoisomer thereof, a tautomer thereof or a solvate thereof, and the aromatic-ring-containing compound can be effectively bounded to bromodomains of BRD4, BRD3, BRD2, and BRDT in BET family to regulate transcription of downstream gene c-myc and related target genes of the c-myc so as to regulate downstream signalingpathways to play specific roles including treatment of diseases such as inflammatory diseases, cancer, and AIDS. Some of the compounds have high activity, and have good cell activity and metabolic stability, so that the compounds can be an effective drug for treating tumors.
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Paragraph 0472-0476
(2018/08/03)
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- ANTI-VIRAL COMPOUNDS
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Compounds effective in inhibiting replication of Hepatitis C virus ("HCV") are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.
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Page/Page column 156-157
(2012/06/30)
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- SUBSTITUTED 5-AMINOPYRAZOLES AND USE THEREOF
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The present application relates to novel substituted 5-aminopyrazoles, methods of production thereof, use thereof alone or in combinations for the treatment and/or prophylaxis of diseases and use thereof for the production of medicinal products for the treatment and/or prophylaxis of diseases.
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Page/Page column 116-117
(2010/04/03)
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- BENZOIMIDAZOLES AS PROLYL HYDROXYLASE INHIBITORS
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The present invention is directed to benzoimidazole compounds of the formula (1) and enantiomers, diastereomers, racemates, and pharmaceutically acceptable salts thereof. Compounds of the present invention are useful in pharmaceutical compositions and met
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Page/Page column 87-88
(2009/12/05)
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- Benzimidazole- and benzoxazole-based inhibitors of Rho kinase
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Inhibitors of Rho kinase have been developed based on two distinct scaffolds, benzimidazoles, and benzoxazoles. SAR studies and efforts to optimize the initial lead compounds are described. Novel selective inhibitors of ROCK-II with excellent potency in b
- Sessions, E. Hampton,Yin, Yan,Bannister, Thomas D.,Weiser, Amiee,Griffin, Evelyn,Pocas, Jennifer,Cameron, Michael D.,Ruiz, Claudia,Lin, Li,Schuerer, Stephan C.,Schroeter, Thomas,LoGrasso, Philip,Feng, Yangbo
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experimental part
p. 6390 - 6393
(2009/09/06)
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