51820-24-7

Basic information

• Product Name: GHCA
• Synonyms: GHCA;INTERMEDIATE OF CEFACLOR
• CAS NO: 51820-24-7
• Molecular Formula: C₂₈H₂₆N₂O₅S
• Molecular Weight: 386.43
• Mol File: 51820-24-7.mol

Chemical Properties

• Boiling Point: 775.7±60.0 °C(Predicted)
• Appearance: /
• Density: 1.39±0.1 g/cm3(Predicted)
• PKA: 12.81±0.60(Predicted)
• CAS DataBase Reference: GHCA(CAS DataBase Reference)
• NIST Chemistry Reference: GHCA(51820-24-7)
• EPA Substance Registry System: GHCA(51820-24-7)

Safety Data

• Hazardous Substances Data: 51820-24-7(Hazardous Substances Data)

Upstream product

• 84532-30-9 3-hydroxy-7-phenylacetamido-3-cephem-4-carboxylic acid benzhydrylester 

Downstream Products

• 51761-90-1 diphenylmethyl 7-amino-3-hydroxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate 

Relevant articles and documents

Method for preparing ceftibuten mother nucleus 7-ANCE

The invention belongs to a method for preparing a ceftibuten mother nucleus 7-ANCE. The method for preparing the ceftibuten mother nucleus 7-ANCE comprises the following steps: S1, reacting a compound A as shown in a formula I with halogenated phosphorus and an acid-binding agent; S2, adding an acid solution to react to generate ammonium salt; and S3, adjusting the pH value of the ammonium salt generated in the step S2 to be neutral or alkaline to obtain a crude product, and purifying to obtain the ceftibuten mother nucleus 7-ANCE, wherein the molar ratio of the compound A to the halogenated phosphorus is 1: (2.5-3.5). Compared with the prior art, the method has the beneficial effects that the reaction is carried out in the rearrangement direction by controlling the molar ratio of the compound A to the phosphorus halide, so that the hydroxyl protection step in the prior art can be omitted, the use of a methylsulfonyl chloride irritant raw material is avoided, and a product with higher purity and yield is obtained.

7β-Amino-cepham-3-ol-4-carboxylic acid compounds

The invention concerns 7β-amino-cepham-3-ol-4-carboxylic acid compounds, particularly esters thereof, and the N-substituted, especially N-acylated derivatives of such compounds, as well as the 3-O-esters of these compounds. They can be used as intermediates, for example, for the manufacture of the corresponding 3-unsubstituted 7β-amino-3-cephem-4-carboxylic acid compounds, which show outstanding pharmacological effects.