Thioesterification and Selenoesterification of Amides via Selective N-C Cleavage at Room Temperature: N-C(O) to S/Se-C(O) Interconversion
The direct nucleophilic addition to amides represents an attractive methodology in organic synthesis that tackles amidic resonance by ground-state destabilization. This approach has been recently accomplished with carbon, nitrogen and oxygen nucleophiles.
Li, Guangchen,Rahman, Md. Mahbubur,Szostak, Michal
supporting information
p. 1060 - 1066
(2020/04/01)
The mechanism of caseinolytic protease (ClpP) inhibition
Catch me if you can: The ClpP protease mediates protein homeostasis and can be efficiently inhibited by β-lactones. A combination of molecular docking, mutagenesis, activity-based protein profiling, and kinetics studies now reveals the mechanism of ClpP inhibition. A hydrophobic pocket next to the active site allows binding of long aliphatic and aromatic residues. The preferred stereoisomer binds into the oxyanion hole. Copyright
Gersch, Malte,Gut, Felix,Korotkov, Vadim S.,Lehmann, Johannes,B?ttcher, Thomas,Rusch, Marion,Hedberg, Christian,Waldmann, Herbert,Klebe, Gerhard,Sieber, Stephan A.
supporting information
p. 3009 - 3014
(2013/04/23)
Synthesis of Β-lactones and alkenes via thiol esters: (E)-2,3-dimethyl-3-dodecene
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Danheiser, Rick L.,Nowick, James S.,Lee, Janette H.,Miller, Raymond F.,Huboux, Alexandre H.,Mathre, David J.,Shinkai, Ichiro
p. 61 - 61
(2017/09/12)
POLYMER-SUPPORTED REAGENTS. THE USE OF ANION-EXCHANGERS IN THE SYNTHESIS OF THIOL ESTERS