Atom-efficient transition-metal-free arylation ofN,O-acetals using diarylzinc reagents through Zn/Zn cooperativity
Exploiting the cooperative action of Lewis acid Zn(C6F5)2with diarylzinc reagents, the efficient arylation ofN,O-acetals to access diarylmethylamines is reported. Reactions take place under mild reaction conditions without the need for transtion-metal catalysis. Mechanistic investigations have revealed that Zn(C6F5)2not only acts as a Lewis acid activator, but also enables the regeneration of nucleophilic ZnAr2species, allowing a limiting 50 mol% to be employed.
Borys, Andryj M.,Gil-Negrete, Jose M.,Hevia, Eva
p. 8905 - 8908
(2021/09/10)
New approach for induction of alkyl moiety to aliphatic amines by NaBH(OAc)3 with carboxylic acid
We had found the novel N-alkylation method, which utilizes carboxylic acids as alkyl sources with sodium triacetoxyborohydride [NaBH(OAc)3]. Our methodology had been revealed to have some advantages over the reported similar procedures. Through
Lewis acid-catalyzed reductive amination of carbonyl compounds with aminohydrosilanes
The TiCl4-catalyzed reaction of aromatic carbonyl compounds with (dialkylamino)dimethylsilanes gave tertiary amines in moderate to high yields. The reductive amination of aliphatic aldehydes was effectively catalyzed by ZnI2. Methyl
Miura,Ootsuka,Suda,Nishikori,Hosomi
p. 1617 - 1619
(2007/10/03)
Semiempirical approach to drug design. Antispasmodic activity of benzhydrylamine derivatives