- An interpenetrated bioactive nonlinear optical MOF containing a coordinated quinolone-like drug and Zn(ii) for pH-responsive release
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A new interpenetrated bioactive nonlinear optical metal-organic framework [Zn2(ppa)2(1,3-bdc)(H2O)] has been designed and synthesized, which shows both a high drug content of 63.9% and a good slow release effect in simulated physical conditions compared to other non-interpenetrated bioactive MOFs. It also shows a large powder second-harmonic generation (SHG) efficiency of 5.6 times that of KH2PO4 (particle size: 150-200 μm). This journal is
- Duan, Li-Na,Dang, Qin-Qin,Han, Cai-Yun,Zhang, Xian-Ming
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- Antibacterial pharmaceutical compositions and processes for preparation thereof
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This invention provides compounds of the following formula SPC1 Wherein R1 is a hydrogen atom, an alkyl group having 1 to 4 carbon atoms, a hydroxyalkyl group having 2 to 4 carbon atoms, a benzyl group, a benzyl group subsituted by methoxy, a phenyl group, a propargyl group or an acyl group; R2 is hydrogen atom, an alkyl group having 1 to 4 carbon atoms, an alkyl group having 2 to 4 carbon atoms substituted by hydroxy or halogen, a vinyl group, an allyl group, or a benzyl group R3 is a hydrogen atom or an alkyl group having 1 to 6 carbon atoms; And salts thereof, and processes for preparing them. Some of the compounds have antibacterial activities.
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- 8-Alkyl-5-oxo-5,8-dihydro-pyrido(2,3-d)pyrimidine-6-carboxylic acids and their preparation
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Valuable antibacterial 8-alkyl-5-oxo-5,8-dihydro-pyrido(2,3-d)pyrimidine-6-carboxylic acids, some of which are new compounds, are made from corresponding pyrimidines by a process involving condensation with an amino-ester, cyclization, halogenation, dehydrohalogenation, and saponification.
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