Ni-Catalyzed Intermolecular Carboacylation of Internal Alkynes via Amide C-N Bond Activation
The Ni-catalyzed carboacylation of alkynes with amide electrophiles and triarylboroxines is presented. The reaction generates all-carbon tetrasubstituted alkene products in up to 62% yield. NiCl2·glyme is used as an inexpensive precatalyst in the absence
Burgett, Russell W.,Kadam, Abhishek A.,Koeritz, Mason T.,Stanley, Levi M.
Acylation of Alkenes with the Aid of AlCl3 and 2,6-Dibromopyridine
Friedel-Crafts-type acylation of alkenes with acyl chlorides has been successfully conducted with a wide substrate scope by the combined use of AlCl3 and 2,6-dibromopyridine. Trisubstituted alkenes afford allylketones or vinylketones depending on the presence or absence of hydrogen atom(s) at the β-position to the acylation site, while monosubstituted alkenes exclusively afford vinylketones.