Catalytic asymmetric 1,3-dipolar cycloaddition of nitrones to alkylidene malonates: Highly enantioselective synthesis of multisubstituted isoxazolidines
All under control! A catalytic asymmetric 1,3-dipolar cycloaddition reaction of nitrones to alkylidene malonates, catalyzed by chiral N,N'-dioxide-Ni(ClO4)2.6 H2O complexes, has been developed with excellent yields, diaste
1,3-DIPOLAR CYCLOADDITION OF DI-1-MENTHYL BENZYLIDENEMALONATE TO (Z)-N,α-DIPHENYLNITRONE: EXPLANATION FOR DIASTEREOSELECTIVITY
1,3-Dipolar cycloaddition of di-1-menthyl benzylidenemalonate to (Z)-N,α-diphenylnitrone proceeds by Si-face preference to give the endo-adduct as the major product among all four possible adducts.An explanation for this diastereofacial selectivity (Si-fa