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52-78-8

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COMPOUNDS FOR TARGETED THERAPIES OF CASTRATION RESISTANT PROSTATE CANCER
The present invention generally relates to new compounds for therapeutic uses. In particular, this disclosure relates to novel tetracyclic compounds useful for treatment of cancer, especially castration resistant prostate cancer. Pharmaceutical composition matters and methods for treating a cancer patient by administering therapeutically effective amounts of such compound alone or together with other therapeutics are within the scope of this disclosure.
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Paragraph 00199; 00200

(2020/09/12)

Synthesis of gon-4-enes
1. A therapeutic composition having progestational activity comprising as active ingredient a 17-aliphatic carboxylic acid ester of 17α-ethynyl-18-methyl-19-nortestosterone and a pharmaceutical carrier for said compound.
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(2008/06/13)

Synthesis of 13-alkyl-gon-4-ones
The preparation of 13-methylgon-4-enes and novel 13-polycarbonalkylgon-4-enes by a new total synthesis is described. 13-Alkylgon-4-enes having progestational, anabolic and androgenic activities are prepared by forming a tetracylic gonane structure unsaturated in the 1,3,5(10),9(11) and 14-positions, selectively reducing in the B- and C-rings, and converting the aromatic A-ring compounds so-produced to gon-4-enes by Birch reduction and hydrolysis.
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(2008/06/13)

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Chemical Properties

Melting Point: 130-136°C
Boiling Point: 447.136 °C at 760 mmHg
Flash Point:190.529 °C
Density: 1.107 g/cm³
Storage Temp.:?20°C
Vapor Pressure: 7.11E-10mmHg at 25°C
Refractive Index: 1.555
PKA: 15.13±0.40(Predicted)
PSA: 37.30000
LogP: 4.26930

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