- Synthesis of 2,4-disubstituted quinolines by reactions of o-isocyano-β-methoxystyrene derivatives with organolithiums
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Alkyl(or aryl)lithiums reacted efficiently with o-isocyano-β-methoxystyrene derivatives, prepared in three steps from o-aminophenyl ketones, to afford the corresponding 2,4-disubstituted quinolines in satisfactory yields.
- Kobayashi, Kazuhiro,Yoneda, Keiichi,Mano, Masaaki,Morikawa, Osamu,Konishi, Hisatoshi
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- A convenient synthesis of quinolines by reactions of o-isocyano-β- methoxystyrenes with nucleophiles
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2,4-Disubstituted quinolines have been synthesized by reactions of o-isocyano-β-methoxystyrenes, which can be easily prepared from commercially available o-aminophenyl ketones in three steps, with alkyl(or aryl)lithiums in generally good yields. Subsequently, o-isocyano-β- methoxystyrenes have also proved to react efficiently with lithium dialkylamides to afford the corresponding 4-substituted N,N-dialkylquinolin-2-amines in satisfactory yields. Graphical Abstract.
- Kobayashi, Kazuhiro,Yoneda, Keiichi,Miyamoto, Kazuna,Morikawa, Osamu,Konishi, Hisatoshi
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p. 11639 - 11645
(2007/10/03)
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