Folate Antagonists. 20. Synthesis and Antitumor and Antimalarial Properties of Trimetrexate and Related 6--2,4-quinazolinediamines
A series of 6--2,4-quinazolinediamines have been prepared by catalytic hydrogenation of the requisite 2,4-diamino-6-quinazolinecarbonitriles in the presence of the appropiate benzenamine.Formylation, acetylation, and nitrosation provide
Elslager, Edward F.,Johnson, Judith L.,Werbel, Leslie M.
p. 1753 - 1760
(2007/10/02)
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