- 3-(Tetrahydropyridinyl)indoles
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Substituted indoles have been condensed with N-benzyl-4-piperidone to give 3-(1-benzyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles. Under basic conditions, 5-, 6-, and 7- (but not 4-) substituted indoles give reasonable yields of the product. For condensation with 4-substituted indoles, acidic conditions and the presence of at least a 3-fold excess of N-benzyl-4-piperidone are beneficial. Under basic conditions, the condensation of indoles with N-substituted-3-piperidones is highly regioselective with the regioselectivity depending on the nature of the N-substituent. 4-Substituted indoles do not react with N-substituted-3-piperidones under basic conditions but give a single product under acidic conditions.
- Gharagozloo, Parviz,Miyauchi, Masao,Birdsall, Nigel J.M.
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p. 10185 - 10192
(2007/10/03)
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- Omega-[4-(3"-indolyl)-piperidino]-alkyl-arylketones as nevroleptics
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Novel [4'-(3"-indolyl)-piperidino]-alkyl-arylketones of the formula SPC1 Wherein R is selected from the group consisting of hydrogen and alkoxy of 1 to 5 carbon atoms, R1 and R2 are individually selected from the group consisting of
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