- Preparation method of dequalinium chloride
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The invention relates to a preparation method of dequalinium chloride. The method comprises the following steps: reacting 2-methyl-4-chloroquinoline, used as a starting material, with p-methoxybenzylamine to obtain an amination intermediate II, carrying out a debenzylation reaction on the intermediate to obtain 2-methyl-4-aminoquinaldine, then reacting the 2-methyl-4-aminoquinaldine with 1,10-diiododecane to obtain dequalinium iodide, continuously reacting the dequalinium iodide with hydrochloric acid to obtain dequalinium chloride, and finally recrystallizing with a mixed solvent to obtain refined dequalinium chloride. The preparation method of the dequalinium chloride does not adopt a highly toxic solvent nitrobenzene, and adopts a nontoxic or low-toxicity solvent, and the reaction temperature is reduced in the reaction process, so the method is environmentally friendly, and the reaction conditions are simple; and the refined dequalinium chloride product is prepared through recrystallization using the mixed solvent, so impurities in the dequalinium chloride process are controllable, the yield and purity of the prepared dequalinium chloride are high, the product quality is stable,and the method is suitable for industrial production.
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- Dequalinium and preparation method thereof
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The invention provides a method for preparing dequalinium and an analogue thereof, and particularly relates to a method for preparing a compound shown in formula I. The method comprises the following steps: (1) adding a compound shown in formula II into a solution containing Cl and water for reaction; (2) adding an oxidant into a product obtained in step (1) for reaction, wherein R and R1 are independently selected from an H atom and C1 to C6 alkyl, and n is 4 to 20. The method is relatively high in yield.
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Paragraph 0087-0088
(2017/07/06)
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- Preparation method of dequalinium chloride and its analogues
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The invention provides a preparation method of dequalinium chloride and its analogues and concretely relates to a preparation method of a compound shown in the formula I. The preparation method comprises (1) adding a compound shown in the formula II into a solution containing Cl and water so that the materials undergo a reaction, and (2) adding an oxidizing agent into the product of the step (1) so that the mixture undergoes a reaction, wherein R and R1 are independently selected from H atoms and C1-C6 alkyl and n is 4-20. The preparation method has a high yield.
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Paragraph 0063; 0092-0097
(2017/07/20)
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