- Facile one-pot direct arylation and alkylation of nitropyridine N -oxides with grignard reagents
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Facile arylation and alkylation of nitropyridine N-oxides were developed through the reactions of Grignard reagents with nitropyridine N-oxides. For the same 4-nitropyridine N-oxide, arylation occurred at the 2- (or 6-) position, whereas alkylation occurred at the 3-position in an adjustably site-selective manner. The cooperative action of the two groups was discovered in the reactions of 3-nitropyridine N-oxides. This protocol can find wide applications in building various pyridine compounds as illustrated in total syntheses of Emoxipin and Caerulomycin A and E.
- Zhang, Fang,Duan, Xin-Fang
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p. 6102 - 6105
(2012/01/06)
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- Bicyclic And Tricyclic Compounds As KAT II Inhibitors
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Compounds of Formula X: wherein A, X, Y, Z, R5, R6a, and R6b are as defined herein, and pharmaceutically acceptable salts thereof, are described as useful for the treatment of cognitive deficits associated with schizophrenia and other neurodegenerative and/or neurological disorders in mammals, including humans.
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Page/Page column 32-33
(2010/12/31)
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- OXIDATIVE DEMETHYLATION OF SOME METHYLNITROPYRIDINE 1-OXIDES
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3-Nitropyridine 1-oxide and 5-methyl-3-nitropyridine 1-oxide are produced readily by oxidative demethylation using SeO2 of 2-methyl- and 2,5-dimethyl-3-nitropyridine 1-oxides.
- Achremowicz, Lucjan
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p. 2433 - 2434
(2007/10/02)
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