- 2-(INDAZOL-5-YL)-6-(PIPERIDIN-4-YL)-1,7-NAPHTHYRIDINE DERIVATIVES AND RELATED COMPOUNDS AS MODULATORS FOR SPLICING NUCLEIC ACIDS AND FOR THE TREATMENT OF PROLIFERATIVE DISEASES
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The present disclosure features compounds of formula (l-a) and of formula (II) and pharmaceutical compositions thereof. The present disclosure further discloses the compounds of formula (I- a) and (II) and their compositions for use in methods of modulating nucleic acid splicing, e.g., splicing of a pre-mRNA, as well as said compounds for use in methods of treating e.g.: ? proliferative diseases, such as e.g. cancer, benign neoplasms or angiogenesis, ? neurological diseases or disorders, such as e.g. Huntington's disease, ? autoimmune diseases or disorders, immunodeficiency diseases or disorders, lysosomal storage disease or disorder, cardiovascular diseases or disorders, metabolic diseases or disorders, respiratory diseases or disorders, renal diseases or disorders, or infectious diseases. Exemplary compounds are e.g. 2-(indazol-5-yl)-6-(piperidin-4-yl)-l,7- naphthyridine derivatives and similar compounds.
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- SYNTHESIS OF THE C-GLYCOSIDE FRAGMENT OF NOGALAMYCIN AND SOME NOGALAMYCIN PRECURSORS
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A short, stereoselective method for generation of the fused C-glycoside unit of the anticancer agent nogalamycin is described; in particular, synthesis of the D,E,F ring system.The method utilises a total synthesis of the glycosidic unit from an aryl fury
- Bates, Mark A.,Sammes, Peter G.,Thomson, Gordon A.
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p. 3037 - 3046
(2007/10/02)
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