524712-41-2

Basic information

• Product Name: 2-CHLORO-5-(3,5-DIOXO-4,5-DIHYDRO-1,2,4-TRIAZIN-2(3H)-YL)BENZOIC ACID
• Synonyms: 2-CHLORO-5-(3,5-DIOXO-4,5-DIHYDRO-1,2,4-TRIAZIN-2(3H)-YL)BENZOIC ACID;Benzoic acid, 2-chloro-5-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3H)-yl)-;2-chloro-5-(3,5-dioxo-4,5-dihydro-1,2,4-triazin-2(3H)-yl)benzoic acid(WXC05767)
• CAS NO: 524712-41-2
• Molecular Formula: C₁₀H₆ClN₃O₄
• Molecular Weight: 267.62534
• Mol File: 524712-41-2.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-CHLORO-5-(3,5-DIOXO-4,5-DIHYDRO-1,2,4-TRIAZIN-2(3H)-YL)BENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-5-(3,5-DIOXO-4,5-DIHYDRO-1,2,4-TRIAZIN-2(3H)-YL)BENZOIC ACID(524712-41-2)
• EPA Substance Registry System: 2-CHLORO-5-(3,5-DIOXO-4,5-DIHYDRO-1,2,4-TRIAZIN-2(3H)-YL)BENZOIC ACID(524712-41-2)

Safety Data

• Hazardous Substances Data: 524712-41-2(Hazardous Substances Data)

Upstream product

• 89-54-3 2-chloro-5-aminobenzoic acid 
• 524712-40-1 C₁₁H₆ClN₃O₆ 

Downstream Products

• 531506-81-7 2-Chloro-5-(3,5-dioxo-4,5-dihydro-3H-[1,2,4]triazin-2-yl)-N-(2-ethyl-butyl)-benzamide 
• 531506-98-6 2-Chloro-5-(3,5-dioxo-4,5-dihydro-3H-[1,2,4]triazin-2-yl)-N-hexyl-benzamide 
• 531506-90-8 2-Chloro-5-(3,5-dioxo-4,5-dihydro-3H-[1,2,4]triazin-2-yl)-N-pentyl-benzamide 
• 531507-00-3 2-Chloro-N-cyclohexylmethyl-5-(3,5-dioxo-4,5-dihydro-3H-[1,2,4]triazin-2-yl)-benzamide 
• 531506-84-0 2-Chloro-5-(3,5-dioxo-4,5-dihydro-3H-[1,2,4]triazin-2-yl)-N-phenethyl-benzamide 
• 531506-89-5 2-chloro-N-[2-(2-chloro-phenyl)-ethyl]-5-(3,5-dioxo-4,5-dihydro-3H-[1,2,4]triazin-2-yl)-benzamide 
• 531507-29-6 2-Chloro-5-(3,5-dioxo-4,5-dihydro-3H-[1,2,4]triazin-2-yl)-N-(1-hydroxy-cyclohexylmethyl)-benzamide 
• 724423-94-3 2-Chloro-N-(1-hydroxy-cycloheptylmethyl)-5-[4-(2-methoxy-ethyl)-3,5-dioxo-4,5-dihydro-3H-[1,2,4]triazin-2-yl]-benzamide 
• 724424-43-5 CE-224,535 
• 531507-27-4 2-Chloro-5-(3,5-dioxo-4,5-dihydro-3H-[1,2,4]triazin-2-yl)-N-[2-(2-trifluoromethyl-phenyl)-ethyl]-benzamide 
• 531507-38-7 2-chloro-5-(3,5-dioxo-4,5-dihydro-3H-[1,2,4]triazin-2-yl)-benzoyl chloride 

Relevant articles and documents

Optimization of the physicochemical and pharmacokinetic attributes in a 6-azauracil series of P2X7 receptor antagonists leading to the discovery of the clinical candidate CE-224,535

High throughput screening (HTS) of our compound file provided an attractive lead compound with modest P2X7 receptor antagonist potency and high selectivity against a panel of receptors and channels, but also with high human plasma protein bindi