- PROSTANOIDS. XII. SYNTHESIS OF THE KEY SYNTHONS AND SOME α-HOMOANALOGS OF 11-DEOXYPROSTAGLANDIN E1
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The cuprate synthesis of the di-, tri,- tetra,- and pentahomoanalogs of 11-deoxyprostaglandin E1 was realized from the corresponding α-homo-2-(butoxycarbonylalkenyl)-2-cyclopenten-1-ones.The latter were obtained by the condensation of 1-morpholinocyclopentene with α,ω-aldehydo esters, prepared by ozonolytic cleavage of cyclic olefins, E,E,E-cyclododecatriene, and undecylenic acid.
- Tolstikov, G. A.,Miftakhov, M. S.,Valeev, F. A.,Akhmetvaleev, R. R.,Khalilov, L. M.,Panasenko, A. A:
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- TOTAL SYNTHESIS OF PROSTAGLANDINS. IV*. SYNTHESIS OF 2-(6-ALKOXYCARBONYLHEXYL)CYCLOPENT-2-EN-1-ONES
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A preparative method was developed for the synthesis of 2-(6-alkoxycarbonylhexyl)cyclopent-2-en-1-ones by the bromination of the respective 2-(6-alkoxycarbonylhexyl)cyclopentan-1-ones with N-bromosuccinimide, followed by dehydrobromination of the bromine-substituted compounds and isomerization of the 2-(6-alkoxycarbonylhexylidene)cyclopentan-1-ones formed as side products.
- Bokaldere, R. P.,Liepinya, A. Ya.,Lozha, E. V.,Lolya, D. O.,Freimanis, Ya. F.
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p. 2119 - 2123
(2007/10/02)
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- Novel 11-alkoxy-9-keto (or hydroxy)-prostenoic acid derivatives and method for preparing same
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This disclosure describes certain 11-alkoxy-9-keto- (or hydroxy)-prostenoic acid derivatives useful as anti-microbial agents, hypotensive agents, anti-ulcer agents, or as intermediates.
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- Novel prostaglandins
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This disclosure describes novel 15-hydroxy prostanoic acid derivatives having anti-ulcer, bronchodilator, and hypotensive activity.
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- Hydro substituted prostanoic acids and esters
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This disclosure describes certain 11-hydroxy and 11-deoxy-9-keto (or hydroxy)prostanoic acid derivatives useful as bronchodilators, anti-ulcer agents, or as intermediates.
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- Novel 11-hydroxy-9-keto-5,6-cis-13,14-cis-prostadienoic acid derivatives
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This disclosure describes certain 11-hydroxy and 11-deoxy-9-keto(or hydroxy)-prostanoic acid derivatives useful as bronchodilators, hypotensive agents, anti-ulcer agents, or as intermediates.
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- Cycloalkyl and cycloalkenyl prostaglandin congeners
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This disclosure describes novel 15-hydroxy prostanoic acids and derivatives thereof useful as bronchodilators, hypotensive agents and gastric acid secretion inhibitors (anti-ulcer).
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- Derivatives of 9-hydroxy-13-trans-prostenoic acid
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This disclosure describes certain 15-deoxy prostanoic acid derivatives having a hydroxy group further along in the beta-chain, useful as bronchodilators, hypotensive agents, anti-ulcer agents, or as intermediates.
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- 3-Alkyl-2-(6-carboxyhexyl)cyclopentanones and esters and salts thereof
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This disclosure describes compounds of the class of substituted 9-oxoprostanoic acids and the esters and cationic salts thereof, useful as antimicrobial agents, hypotensive agents, anti-ulcer agents, or as intermediates, and novel processes for preparing the same.
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- Hydroxylated 15-deoxy derivatives of 9-hydroxy-13-trans-prostenoic acid
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This disclosure describes certain 15-deoxy prostanoic acid derivatives having a hydroxy group further along in the beta-chain, useful as bronchodilators, hypotensive agents, anti-ulcer agents, or as intermediates.
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- 11-Deoxy-13-dihydro-prostaglandin-9-ketals
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This disclosure describes novel 11-deoxy-13,14-dihydro-prostaglandin-9-ketals useful as bronchodilators and as gastric acid secretion inhibitors.
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- Novel 15-substituted prostanoic acids and esters
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This disclosure describes compounds of the class of 15-substituted-9-keto(or 9-hydroxy)prostanoic acids and the esters and cationic salts thereof, useful as inhibitors of gastric acid secretion.
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- Lithium 3-triphenylmethoxy-1-trans-alkenyl-dialkyl alanates
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This disclosure describes 3-triphenylmethoxy-1-alkynes, 3-triphenylmethoxy-1-trans-alkenyl-dialkyl-alanes, and lithium 3-triphenylmethoxy-1-trans-alkenyl-dialkyl alanates useful as intermediates for the preparation of certain 11-hydroxy- and 11-deoxy-9-keto(or hydroxy)-prostanoic acid derivatives which possess bronchodilator, hypotensive, and anti-ulcer activity.
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- 2-Substituted-3,4-epoxycyclopentan-1-ones, and 2-substituted-3,4-epoxycyclopentan-1-ols
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This disclosure describes 2-substituted-3,4-epoxy-cyclopentan-1-ones, 2-substituted-3,4-epoxycyclopentan-1-ols, and various 2-substituted-cyclopentenones useful as intermediates for the preparation of certain 11-hydroxy- and 11-deoxy-9-keto(or hydroxy)-prostanoic acid derivatives which possess bronchodilator, hypotensive, and anti-ulcer activity.
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