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524954-88-9

BENZENAMINE, 3-CHLORO-4-(2-PYRIDINYLTHIO)- is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 524954-88-9 Structure

  • Basic information

    1. Product Name: BENZENAMINE, 3-CHLORO-4-(2-PYRIDINYLTHIO)-
    2. Synonyms: BENZENAMINE, 3-CHLORO-4-(2-PYRIDINYLTHIO)-;TIMTEC-BB SBB005675;[3-chloro-4-(pyridin-2-ylthio)phenyl]amine
    3. CAS NO:524954-88-9
    4. Molecular Formula: C11H9ClN2S
    5. Molecular Weight: 236.72
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 524954-88-9.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: BENZENAMINE, 3-CHLORO-4-(2-PYRIDINYLTHIO)-(CAS DataBase Reference)
    10. NIST Chemistry Reference: BENZENAMINE, 3-CHLORO-4-(2-PYRIDINYLTHIO)-(524954-88-9)
    11. EPA Substance Registry System: BENZENAMINE, 3-CHLORO-4-(2-PYRIDINYLTHIO)-(524954-88-9)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 524954-88-9(Hazardous Substances Data)

524954-88-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 524954-88-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 5,2,4,9,5 and 4 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 524954-88:
(8*5)+(7*2)+(6*4)+(5*9)+(4*5)+(3*4)+(2*8)+(1*8)=179
179 % 10 = 9
So 524954-88-9 is a valid CAS Registry Number.

524954-88-9Downstream Products

524954-88-9Relevant articles and documents

Synthesis and evaluation of 4-anilino-6, 7-dialkoxy-3-quinolinecarbonitriles as inhibitors of kinases of the Ras-MAPK signaling cascade

Berger, Dan,Dutia, Minu,Powell, Dennis,Wu, Biqi,Wissner, Allan,Boschelli, Diane H.,Floyd, M. Brawner,Zhang, Nan,Torres, Nancy,Levin, Jeremy,Du, Xuemei,Wojciechowicz, Donald,Discafani, Carolyn,Kohler, Constance,Kim, Steven C.,Feldberg, Larry R.,Collins, Karen,Mallon, Robert

, p. 3031 - 3034 (2007/10/03)

4-[3-Chloro-4-(1-methyl-1H-imidazol-2-ylsulfanyl)]anilino-6, 7-diethoxy-3-quinolinecarbonitrile (3) was identified as a MEK1 kinase inhibitor with exceptional activity against LoVo cells. The structure-activity relationships of the C-4 aniline substituents were explored, and water-solubilizing groups were added at the C-7 position to improve physical properties. Secondary cellular assays revealed that a compound possessing the appropriate aniline substituents inhibited MEK1 as well as MAPK phosphorylation, thereby acting as a dual inhibitor of the Ras-MAPK signaling cascade.

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