524955-92-8

Basic information

• Product Name: 2-CHLORO-5-FLUORO-4-NITRO-PHENOL
• Synonyms: 2-CHLORO-5-FLUORO-4-NITRO-PHENOL
• CAS NO: 524955-92-8
• Molecular Formula: C₆H₃ClFNO₃
• Molecular Weight: 191.5443232
• Mol File: 524955-92-8.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-CHLORO-5-FLUORO-4-NITRO-PHENOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-5-FLUORO-4-NITRO-PHENOL(524955-92-8)
• EPA Substance Registry System: 2-CHLORO-5-FLUORO-4-NITRO-PHENOL(524955-92-8)

Safety Data

• Hazardous Substances Data: 524955-92-8(Hazardous Substances Data)

Upstream product

• 3827-49-4 2-chloro-5-fluoro-phenol 

Downstream Products

• 932374-66-8 2-chloro-4-nitro-5-fluoroanisole 
• 1229828-47-0 4-benzyloxy-5-chloro-2-fluoro-nitrobenzene 
• 932375-11-6 5-chloro-2-fluoro-4-[(1-methylethyl)oxy]-1-nitrobenzene 
• 1439877-40-3 N-(4-((2-acetamidopyridin-4-yl)oxy)-5-chloro-2-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide 
• 1439879-09-0 N-(5-chloro-4-((2-chloropyridin-4-yl)oxy)-2-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide 
• 1225278-69-2 5-chloro-4-(2-chloropyridin-4-yloxy)-2-fluorophenyl amine 

Relevant articles and documents

PYRIDONE AMIDES AND ANALOGS EXHIBITING ANTI-CANCER AND ANTI-PROLIFERATIVE ACTIVITIES

Compounds useful in the treatment of mammalian cancers and especially human cancers according to Formula I are disclosed. Pharmaceutical compositions and methods of treatment employing the compounds disclosed herein are also disclosed.

Process for the Preparation of Substituted 2-Acetylamino-Alkoxyphenyl

The present invention relates to a novel process for the preparation of compounds of formula (V) wherein X, Q, R1, R1a and R2 are as defined in the specification, the compounds being useful in the preparation of therapeutic agents.

NOVEL BENZODIOXANE AND BENZOXAZINE DERIVATIVES USEFUL AS CC CHEMOKINE RECEPTOR LIGANDS

The present invention relates to benzodioxane and benzoxazine derivatives that act as ligands for CC chemokine receptors, such as CCR1. The invention also relates to methods of preparing the compounds, compositions containing the compounds, and to methods of treatment using the compounds.

NOVEL PROCESS I

The present invention relates to a novel process for the preparation of compounds of Formula (I) wherein X, Q, R1 and R2 are as defined in the specification, the compounds being useful in the preparation of therapeutic agents. The invention further relates to novel intermediates useful in the preparation of the therapeutic agents.

COMPOUNDS WHICH HAVE ACTIVITY AT M1 RECEPTOR AND THEIR USES IN MEDICINE

Compounds of formula (I) and salts and solvates are provided: In a first aspect therefore, the invention provides a compound of formula (I) or a salt or solvate thereof: wherein R5 is selected from halogen, C1-6alkyl, C1-6alkyl substituted with one or more fluorine atoms, C1-6 alkoxy, C1-6 alkoxy substituted with one or more fluorine atoms, and cyano; R6 is selected from halogen, C1-6alkyl, C1-6alkyl substituted with one or more fluorine atoms, C3-6cycloalkyl, C3-6cycloalkyl substituted with one or more fluorine atoms, C1-6 alkoxy, C1-6 alkoxy substituted with one or more fluorine atoms, and cyano; and Q is hydrogen or C 1-6 alkyl. The compounds are M1 agonists and are useful for therapy, for example in the treatment of psychotic disorders and cognitive impairment.