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CAS

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525-41-7

Harmalan, also known as 1-methyl-2,3,4,9-tetrahydro-1H-beta-carboline, is a naturally occurring compound found in a variety of plants, fungi, and animals. It is chemically classified as a beta-carboline alkaloid and has been identified in medicinal plants such as Peganum harmala and Banisteriopsis caapi. Harmalan has been studied for its potential psychoactive and medicinal effects, including its potential as an antidepressant and anti-inflammatory agent. It has also been investigated for its role in the inhibition of monoamine oxidase (MAO) enzymes, which can affect neurotransmitter levels in the brain. Harmalan’s pharmacological properties and potential therapeutic applications continue to be an area of research and interest in the field of natural products and drug discovery.

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  • 525-41-7 Structure

  • Basic information

    1. Product Name: harmalan
    2. Synonyms: harmalan;1-Methyl-4,9-dihydro-3H-pyrido[3,4-b]indole;4,9-Dihydro-1-methyl-3H-pyrido[3,4-b]indole;HarMalane
    3. CAS NO:525-41-7
    4. Molecular Formula: C12H12N2
    5. Molecular Weight: 184.24
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 525-41-7.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 390.3°Cat760mmHg
    3. Flash Point: 189.9°C
    4. Appearance: /
    5. Density: 1.23g/cm3
    6. Vapor Pressure: 2.67E-06mmHg at 25°C
    7. Refractive Index: 1.678
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. CAS DataBase Reference: harmalan(CAS DataBase Reference)
    11. NIST Chemistry Reference: harmalan(525-41-7)
    12. EPA Substance Registry System: harmalan(525-41-7)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 525-41-7(Hazardous Substances Data)

525-41-7 Usage

Uses

Used in Pharmaceutical Industry:
Harmalan is used as a potential antidepressant and anti-inflammatory agent for its psychoactive and medicinal effects.
Used in Drug Discovery:
Harmalan is used as a potential therapeutic agent for its role in the inhibition of monoamine oxidase (MAO) enzymes, which can affect neurotransmitter levels in the brain.

Check Digit Verification of cas no

The CAS Registry Mumber 525-41-7 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,2 and 5 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 525-41:
(5*5)+(4*2)+(3*5)+(2*4)+(1*1)=57
57 % 10 = 7
So 525-41-7 is a valid CAS Registry Number.
InChI:InChI=1/C12H12N2/c1-8-12-10(6-7-13-8)9-4-2-3-5-11(9)14-12/h2-5,13H,6-7H2,1H3

525-41-7Relevant articles and documents

Synthesis of 1-Substituted-2,3,4,9-tetrahydro-(2-oxopropyl)-1H-pyridoindoles and their Base-catalyzed Rearrangements to N-ethyl>acetamides

Bobowski, George

, p. 267 - 272 (2007/10/02)

The condensation of 1H-indole-3-ethanamines, 1, with 2,4-pentanediones, 2, gave enamines 3.Acid catalyzed ring closure of 3 gave 1-(1-substituted-2,3,4,9-tetrahydro-1-(2-oxopropyl)-1H-pyridoindoles 4.Subsequent N-acetylation yielded 5 which sequentially produced 2,3-disubstituted indoles 6 and 7 resulting from C-N bond cleavage after treatment with sodium alkoxide in ethanol.Controlled catalytic hydrogenation of the latter gave saturated derivatives 8 and 9.

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