- Nitroarylhydroxymethylphosphonic acids as inhibitors of CD45
-
A series of nitroarylhydroxymethylphosphonic acids was synthesized and evaluated as inhibitors of CD45. It was discovered that both the alpha hydroxy and nitro groups are essential for activity. Potency is enhanced by the addition of a large lipophilic group on the aryl ring adjacent to the phosphonic acid moiety. Kinetics studies have shown that these compounds are competitive inhibitors and thus bind at the active site of this enzyme.
- Beers, Scott A.,Malloy, Elizabeth A.,Wu, Wei,Wachter, Michael P.,Gunnia, Uma,Cavender, Druie,Harris, Crafford,Davis, Janet,Brosius, Ruth,Pellegrino-Gensey, J. Lee,Siekierka, John
-
p. 2203 - 2211
(2007/10/03)
-
- 10,11-Dihydro-dibenzo(b,f)thiepin derivatives
-
Dibenzothiepin derivatives of the general formula STR1 wherein m, n, R1, R2, R3 and X are as hereinafter set forth, And salts thereof as well as processes for their manufacture are disclosed. The end products are useful as central-depressant and neuroleptic agents.
- -
-
-