Synthesis and biological evaluation of pyridinebetaine A and B
The synthesis of the marine natural products pyridinebetaine A and B is reported. The biological evaluation of pyridinebetaine A and B and several analogues as cytotoxic, antifungal and antiviral agents is also described. Unfortunately, none of the compounds tested showed relevant antifungal or cytotoxic activity. Only pyridinebetaine B reduced the Herpes simplex virus type 1 virus replication, though only weakly.
Gonzalez, Miguel A.,Correa-Royero, Julieth,Mesa, Ana,Betancur-Galvis, Liliana
experimental part
p. 1485 - 1491
(2010/04/23)
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