- THE SYNTHESIS OF 8-HYDROXY- AND 8-METHOXY-ELLIPTICINES
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The first synthesis of 8-hydroxyellipticine is described and its identity with an ellipticine metabolite from Aspergillus alliaceus confirmed.
- Dolman, David,Sainsbury, Malcolm
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- Chemistry of 6H-pyridocarbazoles. Part 9. An Efficient Route to 3-indoles and the Synthesis of Some New Ellipticines
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A new and efficient route to 3-indoles has been developed which requires the Fisher indolisation of 3-(3-pyridyl)butanal with arylhydrazines.The ethylpyridylindoles can be converted into 6H-pyridocarbazoles by a known procedure, leading to the first synthesis of 7-chloro-, 7-fluoro-, 7-methyl-, 8-methoxy-, and 8-hydroxy-ellipticines.The last-named compound is identical with a minor metabolite of ellipticine in Aspergillus alliaceus.
- Sainsbury, Malcolm,Weerasinghe, Deepthi,Dolman, David
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p. 587 - 590
(2007/10/02)
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