Superoxide dismutase mimetics. Part 2: Synthesis and structure-activity relationship of glyoxylate- and glyoxamide-derived metalloporphyrins
Novel glyoxylate- and glyoxamide-derived metalloporphyrins 26-58 were synthesized and evaluated as potential superoxide dismutase (SOD) mimetics. Relative to previously studied MnTBAP analogues, the glyoxylate-derived metalloporphyrins 32, 39, and 54 and glyoxamide-derived metalloporphyrin 49, exhibited enhanced activity in the SOD assay and the majority of the analogues in the current series showed enhanced inhibition of lipid peroxidation and catalase activity.
Trova, Michael P.,Gauuan, Polivina Jolicia F.,Pechulis, Anthony D.,Bubb, Stephen M.,Bocckino, Stephen B.,Crapo, James D.,Day, Brian J.
p. 2695 - 2707
(2007/10/03)
Process for increasing the production or recovery yields of hemiacetal-esters of glyoxylic acid
The process comprises the hot treatment at a temperature of 80° to 160° C. by an amount of 5 to 50% of 85% of phosphoric acid, of the residues resulting from the distillation of reaction media containing hemiacetal-esters under substantially anhydrous conditions. These reaction media are selected from among those resulting from the reaction of alcohols and glyoxylic acid and those resulting from the treatment of glyoxylic hemiacetal-esters with P2 O5.
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(2008/06/13)
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