- Synthesis of potentially photoactivatable coumarin derivatives via a 1,3-dipolar cycloaddition
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(Chemical Equation Presented) A copper (I)-catalyzed 1,3-dipolar cycloaddition reaction was used to prepare a series of mono and disubstituted 1,2,3-triazolyl-coumarins using a 1,3-cycloaddition ("Click Chemistry"). Starting coumarins were synthesized using classical or modified Pechmann's reaction. The propargyl group was introduced as either propargylether or as a propargylamide. Azides were prepared in a three steps procedure. Cycloaddition products, containing a coumarin and a photoactivatable moiety, were obtained in good yields.
- Chenot, Elodie-Denise,Rodriguez-Dominguez, Juan Carlos,Hannewald, Paul,Comel, Alain,Kirsch, Gilbert
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experimental part
p. 1429 - 1435
(2009/04/07)
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- Synthesis of α methyl 4 (2 thienylcarbonyl)benzeneacetic acid, suprofen, and derivatives
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A series of compounds with general structure Het CO Ar CH(CH3)COOH was prepared for pharmacological screening. Different synthetic approaches are described. α Methyl 4 (2 thienylcarbonyl)benzeneacetic acid (compound III-l, suprofen), was found to show a marked antiwrithing activity. Furthermore this compound proved to be a potent inhibitor of prostaglandin biosynthesis.
- van Daele,Boey,Sipido,De Bruyn,Janssen
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p. 1495 - 1501
(2007/10/05)
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