52884-95-4

Basic information

• Product Name: 2-oxo-N-phenylhexanamide
• Synonyms: 2-Oxo-N-phenylhexanamide; hexanamide, 2-oxo-N-phenyl-
• CAS NO: 52884-95-4
• Molecular Formula: C₁₂H₁₅NO₂
• Molecular Weight: 205.253
• Mol File: 52884-95-4.mol

Chemical Properties

• Density: 1.105g/cm³
• Refractive Index: 1.549
• CAS DataBase Reference: 2-oxo-N-phenylhexanamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-oxo-N-phenylhexanamide(52884-95-4)
• EPA Substance Registry System: 2-oxo-N-phenylhexanamide(52884-95-4)

Safety Data

• Hazardous Substances Data: 52884-95-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-oxo-N-phenylhexanamide is used as a precursor for the synthesis of various pharmaceutical drugs, contributing to the development of new medications.
Used in Research and Development:
In the field of research and development, 2-oxo-N-phenylhexanamide is utilized for the study of its biological and pharmacological properties, aiding in the understanding of its potential therapeutic applications.
Used in Pain Management:
2-oxo-N-phenylhexanamide is being investigated for its potential use in the treatment of pain due to its analgesic properties, offering a possible alternative for pain relief.
Used in Mood Disorder Treatment:
2-oxo-N-phenylhexanamide is also being explored for its potential role in the treatment of mood disorders, leveraging its psychoactive properties to address mental health conditions.

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Relevant articles and documents

Manganese(III)-Promoted Double Carbonylation of Anilines Toward α-Ketoamides Synthesis

Employing anilines as nucleophiles in double carbonylation is a longstanding challenge. In this communication, a Mn(III)-promoted double carbonylation of alkylborates or Hantzsch esters with anilines toward the synthesis of α-ketoamides has been developed. By using easily available potassium alkyltrifluoroborates or Hantzsch esters as the starting material, and cheap and non-toxic Mn(OAc)3 ? 2H2O as the promotor, a broad range of alkyl α-ketoamide derivatives were synthesized in moderate to good yields with excellent selectivity. (Figure presented.).

Asymmetric Transfer Hydrogenation of α-Keto Amides; Highly Enantioselective Formation of Malic Acid Diamides and α-Hydroxyamides

The asymmetric transfer hydrogenation (ATH) of α-keto-1,4-diamides using a tethered Ru/TsDPEN catalyst was achieved in high ee. Studies on derivatives identified the structural elements which lead to the highest enantioselectivities in the products. The α-keto-amide reduction products have been converted to a range of synthetically valuable derivatives.

Visible-light initiated copper(i)-catalysed oxidative C-N coupling of anilines with terminal alkynes: One-step synthesis of α-ketoamides

Development of C-N coupling processes is fundamentally important and challenging for the synthesis of biologically active molecules and drugs. Herein, we report a highly atom efficient green process for the synthesis of α-ketoamides via visible-light induced copper(i) chloride catalysed direct oxidative Csp-N coupling reactions using commercially available alkynes and anilines at room temperature without the use of hazardous chemicals and harsh reaction conditions. Forty-seven examples are presented using a broad range of substrates including electron deficient anilines and various terminal alkynes. The current photochemical process is able to achieve epoxide hydrolase inhibitors in one step with high yield (92-95%). This transformation is highly efficient and highly selective for the synthesis of α-ketoamides. This journal is

Iodine-mediated oxidation of ynamides: A facile access to N-monosubstituted α-ketoamides and α-ketoimides

An efficient iodine-mediated oxidation reaction for ynamides has been developed to produce N-monosubstituted α-ketoamides and α-ketoimides. This oxidative method, which exhibits good functional group tolerance, was performed under mild conditions without a metal catalyst.

Syntheses of Dialkyl and Functionalized Ketones via 1-(Benzotriazol-1-yl)alkyl Methyl Thioethers

Benzotriazol-1-ylmethyl methyl thioether (1), after easy deprotonation by BuLi, reacted with alkyl halides to afford 1-(benzotriazol-1-yl)alkyl methyl thioethers 2 in good yields. The utility of compounds 2 as alkanoyl anion equivalents was demonstrated by the reactions of their anions with alkyl halides, aldehydes, ketones, esters, and phenyl isocyanate: the products were readily hydrolyzed to α-functionalized ketones in dilute aqueous acid.

Substituted (Carbazol-9-yl)(benzotriazol-1-yl)methanes: Novel Acyl Anion Equivalents

Alkyl(carbazol-9-yl)(benzotriazol-1-yl)methanes are deprotonated by BuLi to form anions which react with alkyl halides, aldehydes, and isocyanates to afford the expected products and which add 1,4 to α,β-unsaturated ketones.These products are hydrolyzed by dilute acid at ambient temperature to afford the corresponding ketones.