Design and structure-activity relationships of 2-alkyl-3-aminomethyl-6-(3-methoxyphenyl)-7-methyl-8-(2-fluorobenzyl) imidazolo[1,2-α]pyrimid-5-ones as potent GnRH receptor antagonists
SAR studies of 7-phenylpyrrolo[1,2-α]pyrimid-4-ones 1 and 2, and 2-phenylimidazolo[1,2-α]-pyrimidines 3 and 4, as nonpeptide human GnRH receptor antagonists, lead us to believe that the aromatic ring at position-2 of 4 is no longer crucial for the binding
Zhu, Yun-Fei,Guo, Zhiqiang,Gross, Timothy D.,Gao, Yinghong,Connors Jr., Patrick J.,Struthers, R. Scott,Xie, Qiu,Tucci, Fabio C.,Reinhart, Greg J.,Wu, Dongpei,Saunders, John,Chen, Chen