- 10-Hydroxy PGC compounds
-
10α-Hydroxy-11-desoxy-prostaglandin analogs of the PGE1 and PGE2 and PGF1α and PGF2α series, the 11-dehydro derivatives thereof as well as the 9,10-ketals in the PGF series, and methods of preparing same, 9-keto-10α,15α-dihydroxyprosta-13-trans-enoic or 5-cis,13-trans-dienoic acid, 9α,10α,15α-trihydroxyprosta-11,13-trans-dienoic or 5-cis, 11,13-trans-trienoic acid and 9α,10α-isopropyli-denedioxy-15α-hydroxyprosta-13-trans-enoic or 5-cis,13-trans-dienoic acid are representative of the class. Also included are the corresponding pharmaceutically acceptable, non-toxic esters, ethers and salts. These compounds possess prostaglandin-like activity and thus are useful in the treatment of mammals, where prostaglandins are indicated.
- -
-
-
- Substituted prostaglandin derivatives
-
Prostaglandin analogs of the PGF2α, PGE2, PGF1α and PGE1 series substituted at C-10α by a hydroxyl group, the derivatives of the PGF1α and PGE1 series further substituted at C-5,6 by a methylene or dihalomethylene group, and the 10,11-ketals thereof and methods of preparing such compounds. 9α,15α-Dihydroxy-10α,11α-isopropylidenedioxyprosta-5,13-dienoic acid, 9-keto-10α,11α-isopropylidenedioxy-15α-hydroxyprosta-5,13-dienoic acid and 5,6-methylene-9α,15α-dihydroxy-10α,11α-isopropylidenedioxyprost-13-enoic acid are representative of the class. Also included are the corresponding esters, ethers, pharmaceutically acceptable salts and amides. These compounds possess prostaglandin-like activity and thus are useful in the treatment of mammals, where prostaglandins are indicated.
- -
-
-