- Synthesis and anticancer evaluation of bis(benzimidazoles), bis(benzoxazoles), and benzothiazoles
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Four classes of UK-1 analogues were synthesized and their cytotoxicity testing against human A-549, BFTC-905, RD, MES-SA, and HeLa carcinoma cell lines was determined. The results revealed that UK-1 and four of these analogues (15-18) are potent against the cancer cell lines. In particular, compound 16 is more potent than UK-1 against A-549 and HeLa cell lines, and compounds 15, 17, and 18 selectively exhibit potent cytotoxic activity against the BFTV-905 cells (IC50 9.6 μM), A-549 cells (IC50 6.6 μM), and MES-SA cells (IC50 9.2 μM), respectively.
- Huang, Shu-Ting,Hsei, I-Jen,Chen, Chinpiao
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p. 6106 - 6119
(2007/10/03)
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- UK-1 analogues: methods of preparation and use
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The present invention includes a number of structural analogues of UK-1. A comparision of the anticancer activity of the UK-1 analogues with their ability to inhibit the growth of methicillin-sensitive and methicillin-resistant Staphylococcus aureus demon
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Page 8; sheet 2
(2010/02/10)
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- Synthesis and evaluation of anticancer benzoxazoles and benzimidazoles related to UK-1
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UK-1 is a structurally unique bis(benzoxazole) natural product isolated from a strain of Streptomyces. UK-1 has been reported to possess anticancer activity but no activity against bacteria, yeast, or fungi. Previous work has also demonstrated the ability
- Kumar, Devinder,Jacob, Melissa R.,Reynolds, Michael B.,Kerwin, Sean M.
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p. 3997 - 4004
(2007/10/03)
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