- A cascade Aza-Cope/Aza-prins cyclization leading to piperidine derivatives
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The cascade aza-Cope/aza-Prins cyclization of homoallylamines to give substituted piperidines has been explored. The use of glyoxalic acid as the carbonyl component afforded bicyclic structures as a result of the internal carboxylate anion trapping the intermediate cation. The unimolecular bis-, tris-, and tetrakis(homoallylamine)s efficiently delivered the appended bis-, tris- and tetrakis(piperidine-4-ol)s (tripod and crucifix shape, respectively) as new entities. The latter compound served as an excellent ligand in the Suzuki-Miyaura cross-coupling reaction to synthesize incrustoporin. The cascade aza-Cope/aza-Prins cyclization of homoallylamines to give substituted piperidines is described. A unimolecular tetrapiperidine derivative, which resulted from this strategy, was employed as a ligand in the Suzuki-Miyaura cross-coupling reaction of an α-iodobutenolide with an arylboronic acid in an efficient synthesis of incrustoporin and its analogues.
- Nallasivam, Jothi L.,Fernandes, Rodney A.
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- Isomerization method for bis(amino-methyl)cyclohexane
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An isomerization method for bis(amino-methyl)cyclohexane has an isomerization step for isomerizing bis(amino-methyl)cyclohexane in the presence of an imine compound represented by general formula (1) and one or more type of compound selected from the group comprising an alkali metal, an alkali-metal-containing compound, an alkali earth metal, and an alkali-earth-metal-containing compound. (In general formula (1), R1 and R2 each independently indicates a monovalent group selected from the group comprising a hydrogen atom, a substituted or un-substituted hydrocarbon group, a substituted or un-substituted alkoxy group, and an acyl group. (R1 and R2 may be bonded to each other and form a ring.) R3 indicates an n-valent group selected from the group comprising a hydrogen atom and a substituted or un-substituted hydrocarbon group, n being an integer from 1 to 10.).
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Paragraph 0256; 0257; 0258
(2016/10/10)
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- ISOMERIZATION METHOD FOR BIS (AMINOMETHYL) CYCLOHEXANE
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A method for isomerizing a bis(aminomethyl)cyclohexane, including an isomerization step of isomerizing the bis(aminomethyl)cyclohexane in the presence of an imine compound represented by the following general formula (1) and at least one compound selected
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Paragraph 0175
(2016/08/17)
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- Benzylated Polyamine Curing Agents
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A curing agent composition including at least one benzylated polyamine compound. The benzylated polyamine compound is a reaction product of a benzaldehyde compound or benzyl halide compound and a polyamine according to the following formula: [in-line-formulae]H2N—CH2-A-CH2-NH2[/in-line-formulae] where A is a phenylene group or a cyclohexylene group. A method for making the curing agent composition and an amine-epoxy composition are also disclosed.
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Paragraph 0076
(2013/04/10)
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- SYNTHESIS, NMR INVESTIGATION AND FAB-MS CHARACTERIZATION OF 1-AMINO-2-ARYLMETHYL-DIPHOSPHONATE ESTERS
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Variously substituted amino aryl-methyl-diphosphonate ethyl esters have been prepared in good yields by adding diethyl phosphonate to the corresponding Schiff bases.All compounds were characterized by NMR and MS-FAB techniques, which reveal the presence o
- Failla, Salvatore,Finocchiaro, Paolo,Hagele, Gerhard,Rapisardi, Roberto
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