- Method for preparing 7-phenylacetylamino-3-hydroxyl-3-cyclo-4-p-nitrobenzyl cephalosporin carboxylate
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The invention belongs to the field of preparation methods for compounds and particularly relates to a method for preparing 7-phenylacetylamino-3-hydroxyl-3-cyclo-4-p-nitrobenzyl cephalosporin carboxylate. The 7-phenylacetylamino-3-hydroxyl-3-cyclo-4-p-nitrobenzyl cephalosporin carboxylate is prepared from thiazoline enol ester, which serves as a raw material, by a one-pot method through acylation, ene-amination, bromization and cyclization. According to the method, through one-pot method continuous reactions, the operation is simple, the total reaction time is shortened, and the energy consumption is greatly lowered; and the reaction process is carried out at normal temperature or under the condition of being close to room temperature, the reaction conditions are mild, the reaction time is relatively short, the raw materials used are readily available, the cost is low, the pollution is light, the total yield reaches 82.5% or more, the purity can reach 98.0% or more, and the quality of the product is relatively good, so that the method is applicable to industrial production.
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Paragraph 0033-0035
(2017/09/02)
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- An efficient method for the reduction of cephalosporin sulfoxides
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An efficient and convenient method for the reduction of cephalosporin sulfoxides to their corresponding sulfides by Lawesson reagent is reported.
- Tewari, Neera,Kumar, Yatendra,Thaper, Rajesh K.,Khanna, Jag Mohan
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p. 1169 - 1173
(2007/10/03)
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