Synthesis, spectroscopic characterization, X-ray structure and biological screenings of organotin(IV) 3-[(3,5-dichlorophenylamido)]propanoates
Six new organotin(IV) complexes with general formula R3SnL/ R2SnL2 where R = CH3 (1, 4), n-C 4H9 (2, 5), C6H5 (3) or C 8H17 (6) and L = 3-[(3,5-d
Shah, Farooq Ali,Sirajuddin, Muhammad,Ali, Saqib,Abbas, Syed Mustansar,Tahir, Muhammad Nawaz,Rizzoli, Corrado
p. 159 - 168
(2013/07/31)
Synthesis and SAR of a novel positive allosteric modulator (PAM) of the metabotropic glutamate receptor 4 (mGluR4)
This Letter describes the synthesis and SAR of the novel positive allosteric modulator, VU0155041, a compound that has shown in vivo efficacy in rodent models of Parkinson's disease. The synthesis takes advantage of an iterative parallel synthesis approach to rapidly synthesize and evaluate a number of analogs of VU0155041.
Williams, Richard,Johnson, Kari A.,Gentry, Patrick R.,Niswender, Colleen M.,Weaver, Charles D.,Conn, P. Jeffrey,Lindsley, Craig W.,Hopkins, Corey R.
scheme or table
p. 4967 - 4970
(2010/03/24)
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