53258-95-0Relevant articles and documents
Synthesis of β-heteroaryl carbonyl compounds via direct cross-coupling of allyl alcohols with heteroaryl boronic acids under cooperative bimetallic catalysis
Zhu, Mingxiang,Du, Hongli,Li, Jingya,Zou, Dapeng,Wu, Yusheng,Wu, Yangjie
, p. 1352 - 1355 (2018/03/06)
The eco-friendly cooperative Cu/Pd-catalyzed oxidative Heck reaction of allyl alcohols with heteroaryl boronic acids under air was described. The ready availability of starting materials and the mild reaction conditions made this protocol a safe and operationally convenient strategy for the efficient synthesis of β-heteroaryl carbonyl compounds.
Synthesis of benzofuro[3,2-b]pyridines via palladium-catalyzed dual C-H activation of 3-phenoxypyridine 1-oxides
Sun, Wei,Wang, Min,Zhang, Yicheng,Wang, Lei
supporting information, p. 426 - 429 (2015/03/03)
An efficient oxidative cyclization to straightforward synthesis of benzofuro[3,2-b]pyridine 1-oxides with high regioselectivity via Pd-catalyzed intramolecular dual C-H activation was developed. The resulting products could be deoxygenated easily to the corresponding benzofuro[3,2-b]pyridines in excellent yields.
3,3'-Oxybispyridine and the Polarographic Reduction of 1,1'-Dimethyl-3,3'-oxybispyridinediium Diiodide
Barker, David J.,Summers, Lindsay A.
, p. 1411 - 1412 (2007/10/02)
3,3'-Oxybispyridine is prepared by reaction of 3-hydroxypyridine with 3-bromopyridine and converted to the 1,1'-dimethyl diquaternary salt with methyl iodide.The salt is reduced polarographically by a one electron transfer not involving hydrogen to an unstable radical cation at a potential (E0) of -0.81 V in the pH range 6.3-12.0.
Cognition-Activating Properties of 3-(Aryloxy)pyridines
Butler, Donald E.,Poschel, B. P. H.,Marriott, John G.
, p. 346 - 350 (2007/10/02)
A series of 3-(aryloxy)pyridines was found to possess activity in enhancing retention for passive avoidance learning in mice.This test was used to select compounds with potential therapeutic properties for the treatment of cognitive disorders.Reference drugs that gave positive results in this procedure included d-amphetamine, magnesium pemoline, methyl phenidate, picrotoxin, phenytoin, and ethosuximide.All active compounds gave inverted U-shaped doseresponse curves.The most active compounds of the 3-(aryloxy)pyridines included 3-phenoxypyridine (1), 3-(2-fluorophenoxy)pyridine (2), 3-(4-fluorophenoxy)pyridine (4), 3,3'-oxybis(pyridine) (23), and 3,3'-oxybis(pyridine) 1-oxide (24). 3-Phenoxypyridine (1) was clearly superior to all of the analogues tested in terms of the level of retention, grammometric potency, and the breadth of its inverted U-shaped dose-response curve.It was given the designation of CI-844 and after a detailed study of its pharmacological profile was submitted for preclinical toxicology.
