- A novel photoaffinity probe for the LTD4 receptor
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A novel photoaffinity probe for the leukotriene D4 receptor (LTD4) is described. L-745310, which is structurally related to the potent LTD4 antagonist MK-0476 (Singulair(TM)), was found to selectively label a 43-kDa protei
- Gallant, Michel,Sawyer, Nicole,Metters, Kathleen M.,Zamboni, Robert J.
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- A rigid metallohexameric macrocycle composed of endo- and exo-cyclic bisterpyridine-metal complexes
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Synthesis of terpyridine-based building blocks has allowed the self-assembly of a nanosized metallomacrocycle with precisely positioned, peripheral metal complexes. Construction of the precursors included the assembly of a heteroleptic bisterpyridine-Ru(ii) complex possessing a diiodoaryl moiety that was subsequently reacted with two equivalents of 4′-ethynyl-2, 2′:6′,2′′-terpyridine via a Pd(0)-catalyzed Sonagashira coupling, to generate the requisite monomer with two, 120°-juxtaposed metal coordination sites. Addition of one equivalent of Fe(ii) to one equivalent of the bisligand afforded the metallocycle with 12 metals [6 internal Fe(ii) ions and 6 external Ru(ii) ions] measuring ca. 7 nm in diameter.
- Li, Sinan,Moorefield, Charles N.,Shreiner, Carol D.,Wang, Pingshan,Sarkar, Rajarshi,Newkome, George R.
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experimental part
p. 2130 - 2135
(2011/11/13)
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- Conjugated oligoyne-bridged [60]fullerene molecular dumbbells: Syntheses and thermal and morphological properties
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Chemical Equation Presented A series of linear and star-shaped π-conjugated oligomer hybrids (2-5) composed of an oligoyne core, ranging from 1,3-butadiyne to 1,3,5,7,9,11-dodecahexayne, and fullerenyl end-capping groups has been synthesized and studied.
- Zhou, Ningzhang,Zhao, Yuming
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experimental part
p. 1498 - 1516
(2010/05/02)
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- Solid-phase approaches toward cyclic oligomers
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Strategies were sought to effect cyclizations of oligo(m-phenylene ethynylene) by exploiting pseudo-high dilution effects on polymer supports. Using Pd/Cu-catalyzed coupling protocols, Merrifield's resin (1% crosslinked chloromethylated polystyrene) proved inadequate for site isolation; inter-site couplings ensued on the flexible support. Conversely, use of the Argopore resin, a more highly crosslinked polystyrene, inhibited inter-site interactions, and no identifiable final product could be separated from the resin. Spectroscopic and mass spectrometric methods indicated that the product from the Argopore resin might be a threaded catenane.
- Shortell, David B.,Palmer, Liam C.,Tour, James M.
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p. 9055 - 9065
(2007/10/03)
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- Synthetic studies on dendritic glycoclusters: A convergent palladium-catalyzed strategy
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A facile Pd-catalyzed strategy by which multiantennary glycoclusters and sugar dendrons can be readily assembled in one-step is described.
- Sengupta, Saumitra,Sadhukhan, Subir Kumar
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p. 215 - 219
(2007/10/03)
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- Iodo-aryl carbonates for use in methods in radiography
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A method for using iodo-aryl carbonates, such as for example, p-iodo-benzyl carbonates, p-iodo-sec-phenethyl carbonates, p-iodo-phenethyl carbonates, p-iodo-phenyl carbonates, 3-(p-iodophenyl)propyl carbonates, 3-(p-iodophenyl)butyl carbonates, 2-(p-iodobenzyl)butyl carbonates and 2-(p-iodobenzyl)-n-hexyl carbonates, to provide radiopaques for various radiography purposes in connection with such techniques as X-ray applications including myelography, salpingography, lymphography and bronchography. The method first comprises selecting a compound generally categorized as a carbonate and having the general formula STR1 wherein R represents an alkyl group having from 1 to 10 carbon atoms and R' represents an iodinated phenyl linked directly to the ester oxygen or through an alkyl chain consisting of 1 to 3 carbon atoms. An effective amount of a pharmaceutically acceptable carbonate, as defined herein, is then placed into the subject body cavity and the particular X-ray or other study performed of this area.
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- Iodine containing organic carbonates for use as radiographic agents
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Iodo-aryl carbonates, such as for example, p-iodo-benzyl carbonates, p-iodo-sec-phenethyl carbonates, p-iodo-phenethyl carbonates, p-iodo-phenyl carbonates, 3-(p-iodophenyl)propyl carbonates, 3-(p-iodophenyl)butyl carbonates, 2-(p-iodobenzyl)butyl carbonates and 2-(p-iodobenzyl)-n-hexyl carbonates, for use as radiographic media in connection with such techniques as x-ray applications including myelography, salpingography, lymphography and bronchography. An effective quantity of iodinated organic carbonate provides x-ray contrast, and the compounds of the invention may be characterized generally as carbonates having the general formula STR1 wherein R represents an alkyl group having from 4 to 10 carbon atoms and R' represents an iodinated phenyl linked to the ester oxygen through an alkyl chain consisting of 1 to 3 carbon atoms.
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