Organocatalytic diboration involving "reductive addition" of a boron-boron-bond to 4,4′-bipyridine
A 4,4′-bipyridine-based catalyst system for diboration of pyrazine derivatives was established. The catalyst cycle consists of the following two steps: (1) reductive addition of the boron-boron bond of bis(pinacolato)diboron to 4,4′-bipyridine to form N,N
Design and synthesis of 3,7-diarylimidazopyridines as inhibitors of the VEGF-receptor KDR
3,7-Diarylsubstituted imidazopyridines were designed and developed as a new class of KDR kinase inhibitors. A variety of imidazopyridines were synthesized and potent inhibitors of KDR kinase activity were identified with good aqueous solubility.
Wu, Zhicai,Fraley, Mark E.,Bilodeau, Mark T.,Kaufman, Mildred L.,Tasber, Edward S.,Balitza, Adrienne E.,Hartman, George D.,Coll, Kathleen E.,Rickert, Keith,Shipman, Jennifer,Shi, Bin,Sepp-Lorenzino, Laura,Thomas, Kenneth A.
p. 909 - 912
(2007/10/03)
Synthesis of (pyridinyl)-1,2,4-triazolo[4,3-a]pyridines
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Moran,Morton,Albright
p. 1071 - 1077
(2007/10/02)
(Pyridinyl)-1,2,4-triazolo[4,3-a]pyridines
This disclosure describes novel substituted 1,2,4-triazolo[4,3-a]pyridines which possess anxioltic activity.
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(2008/06/13)
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