- Structure-based design, synthesis, and biological evaluation of 1,1-dioxoisothiazole and benzo[b]thiophene-1,1-dioxide derivatives as novel inhibitors of hepatitis C virus NS5B polymerase
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A novel series of HCV NS5B polymerase inhibitors comprising 1,1-dioxoisothiazoles and benzo[b]thiophene-1,1-dioxides were designed, synthesized, and evaluated. SAR studies guided by structure-based design led to the identification of a number of potent NS
- Kim, Sun Hee,Tran, Martin T.,Ruebsam, Frank,Xiang, Alan X.,Ayida, Benjamin,McGuire, Helen,Ellis, David,Blazel, Julie,Tran, Chinh V.,Murphy, Douglas E.,Webber, Stephen E.,Zhou, Yuefen,Shah, Amit M.,Tsan, Mei,Showalter, Richard E.,Patel, Rupal,Gobbi, Alberto,LeBrun, Laurie A.,Bartkowski, Darian M.,Nolan, Thomas G.,Norris, Daniel A.,Sergeeva, Maria V.,Kirkovsky, Leo,Zhao, Qiang,Han, Qing,Kissinger, Charles R.
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supporting information; scheme or table
p. 4181 - 4185
(2009/04/16)
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- Process for preparing substituted aromatic and heteroaromatic aldehydes and carboxylic acids
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A process for preparing substituted aromatic and heteroaromatic aldehydes or carboxylic acids of the formula in which R1and R2are H, C1-C4alkyl, C1-C4alkoxy, OH, NO2, CN, COOH, C
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- Process for preparing 2-carboxy-5-nitrobenzenesulfonic acid and salts thereof by oxidation
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The invention is directed to a simple process for the preparation of the product 2-carboxy-5-nitrobenzenesulfonic acid (=4-nitro-2-sulfo-benzoic acid) or a salt thereof. The product can be prepared by the oxidation reaction of 2-methyl-5-nitrobenzenesulfo
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