Catalytic activation of carbohydrates as formaldehyde equivalents for stetter reaction with enones
We disclose the first catalytic activation of carbohydrates as formaldehyde equivalents to generate acyl anions as one-carbon nucleophilic units for a Stetter reaction. The activation involves N-heterocyclic carbene (NHC)-catalyzed C-C bond cleavage of carbohydrates via a retro-benzoin-type process to generate the acyl anion intermediates. This Stetter reaction constitutes the first success in generating formal formaldehyde-derived acyl anions as one-carbon nucleophiles for non-self-benzoin processes. The renewable nature of carbohydrates, accessible from biomass, further highlights the practical potential of this fundamentally interesting catalytic activation.
Zhang, Junmin,Xing, Chong,Tiwari, Bhoopendra,Chi, Yonggui Robin
p. 8113 - 8116
(2013/07/19)
Highly atom economical uncatalysed and I2-catalysed silylation of phenols, alcohols and carbohydrates, using HMDS under solvent-free reaction conditions (SFRC)
An uncatalysed silylation of phenols, regardless on the aggregate state and nature of the substituents with 0.55 equiv of HMDS under solvent-free reaction conditions (SFRC) at room temperature is reported. Sterically hindered phenols, carbohydrates and most of the alcohols additionally required a catalytic amount (up to 2 mol %) of iodine. The reaction protocol is very simple; obtaining a pure product, particularly of uncatalysed reactions, was frequently a completely solvent-free process.
Jereb, Marjan
experimental part
p. 3861 - 3867
(2012/06/30)
Catalysts for Silylations with 1,1,1,3,3,3-Hexamethyldisilazane
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Bruynes, Cornelis A.,Jurriens, Theodorus K.
p. 3966 - 3969
(2007/10/02)
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