535925-49-6

Basic information

• Product Name: 2-chloro-5-fluoro-1H-indole-3-carbaldehyde
• Synonyms: 2-chloro-5-fluoro-1H-indole-3-carbaldehyde
• CAS NO: 535925-49-6
• Molecular Formula: C9H5ClFNO
• Molecular Weight: 197.6
• Mol File: 535925-49-6.mol

Chemical Properties

• Boiling Point: 367.9±37.0 °C(Predicted)
• Appearance: /
• Density: 1.523±0.06 g/cm3(Predicted)
• PKA: 13.06±0.30(Predicted)
• CAS DataBase Reference: 2-chloro-5-fluoro-1H-indole-3-carbaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-5-fluoro-1H-indole-3-carbaldehyde(535925-49-6)
• EPA Substance Registry System: 2-chloro-5-fluoro-1H-indole-3-carbaldehyde(535925-49-6)

Safety Data

• Hazardous Substances Data: 535925-49-6(Hazardous Substances Data)

Upstream product

• 56341-41-4 5-fluoroindol-2(3H)-one 
• 68-12-2 N,N-dimethyl-formamide 

Relevant articles and documents

BENZOFURAN-BASED N-ACYLHYDRAZONE DERIVATIVES AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

A benzofuran-based N-acylhydrazone derivative according to the present invention has an excellent anticancer effect while having low toxicity and excellent solubility, and, thus, a pharmaceutical composition comprising the derivative can be usefully used to prevent or treat a cell proliferative disorder including various cancers. To this end, the present invention provides a compound represented by chemical formula 1, a stereoisomer thereof, or a pharmaceutically acceptable salt thereof.

A cascade deprotonation/intramolecular aldol reaction of α-carbonyl sulfonium ylides with 2-mercaptoindole-3-carbaldehydes and 2-mercaptobenzaldehydes to access thieno[2,3-b]indoles and benzothiophenes

The first catalyst-free cascade deprotonation/intramolecular aldol reaction of α-carbonyl sulfonium ylides with 2-mercaptoindole-3-carbaldehydes and 2-mercaptobenzaldehydes was developed. A series of thieno[2,3-b]indoles and benzothiophenes were smoothly obtained in high to excellent yields. The salient features of the protocol include catalyst-free conditions, an environment-friendly solvent, broad substrate scope, and large-scale synthesis.

Organocatalytic enantioselective tandem sulfa-Michael/aldol reaction to access dihydrothiopyran-fused benzosulfolane skeletons bearing three contiguous stereocenters

The first organocatalytic diastereo- and enantioselective tandem sulfa-Michael/aldol reaction of 2-mercaptoindole-3-carbaldehydes and 2-mercaptobenzaldehydes with benzo[b]thiophene sulfones was developed. With multiple hydrogen-bonding thiourea as a catalyst, a wide range of polycyclic dihydrothiopyran-fused benzosulfolanes were smoothly obtained with excellent results (up to 99% yield, 420 : 1 dr and 99% ee) under mild reaction conditions.