- Pyrazolo [1,5-a] [1,3,5] triazine derivatives and their salts and their applications in the preparation of anticancer drugs
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The present invention discloses a class of pyrazolo [1,5-a] [1,3,5] triazine derivatives and salts thereof and applications in the preparation of anticancer drugs, the structure of the derivative is R' is benzothiophene-3-yl or 1-methylindole-3-yl; R is -NHCH2CH2R "diethylaminoeoxy, N,N,N'-trimethylethylenediamino, 4-(2-methoxyethyl) piperazine group, piperazinyl, diethylamino, 4- Methylpiperazine, 4-acryloylpiperazine, or wherein R" is diethylamino, morpholine, 4-methylpiperazine or pyrrolidinyl, R1 is acryloylamino, 4-(dimethylamino)butyl-2-enoamido or N-methylpyrrolidine-2-ylimino;R2 It is one or two of fluorine, methoxy, dimethylamino, morpholine, diethylamino, thiomorpholine, 4-methylpiperazine, N, N,N'-trimethylethylenediamino; The present invention is pyrazolo [1,5-a] [1,3,5] triazine derivatives and salts thereof have a significant inhibitory effect on the proliferation of human cancer cells, can be used to prepare anti-cancer drugs.
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Paragraph 0112-0114; 0124-0126
(2022/04/03)
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- 4-Fluoro-3-nitro anilines
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Compounds of formula: SPC1 Wherein W is EQU1 or EQU2 in which: (a) R4 and R5 are 5 identical or different and represent hydrogen, monovalent aliphatic, substituted or unsubstituted aryl, aralkyl and cycloalkyl, providing that not more than 1 of R4 or R5 is hydrogen, and (b) R3 is a divalent aliphatic radical.
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