53731-99-0

Basic information

• Product Name: 5-CHLORO-2-METHYLBENZAMIDE
• Synonyms: 5-CHLORO-2-METHYLBENZAMIDE;(R)-alpha-Bromo-alpha-(4-chloro-phenyl)acetonitrile;(R)-Bromo-(4-chloro-phenyl)-acetonitrile;Benzeneacetonitrile, .alpha.-broMo-4-chloro-;2-Bromo-2-(4-chlorophenyl)acetonitrile
• CAS NO: 53731-99-0
• Molecular Formula: C₈H₅BrClN
• Molecular Weight: 230.49
• Mol File: 53731-99-0.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-CHLORO-2-METHYLBENZAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-CHLORO-2-METHYLBENZAMIDE(53731-99-0)
• EPA Substance Registry System: 5-CHLORO-2-METHYLBENZAMIDE(53731-99-0)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 53731-99-0(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
5-CHLORO-2-METHYLBENZAMIDE is used as a building block in organic synthesis for creating other organic compounds. Its unique structure allows for various chemical reactions, making it a valuable component in the synthesis of complex organic molecules.
Used in Pharmaceutical Research:
In pharmaceutical research, 5-CHLORO-2-METHYLBENZAMIDE is utilized as an intermediate in the synthesis of various biologically active compounds. Its potential as a precursor for developing new drugs makes it an essential tool in drug discovery and development.
Used in Agrochemical Production:
5-CHLORO-2-METHYLBENZAMIDE is employed in the production of agrochemicals, where it serves as a key intermediate for the synthesis of active ingredients in pesticides and other agricultural chemicals. Its contribution to the development of effective agrochemicals helps improve crop protection and yield.
Used in Veterinary Drug Development:
In the veterinary industry, 5-CHLORO-2-METHYLBENZAMIDE is used as a building block for the synthesis of veterinary drugs. Its role in creating effective medications for animals contributes to the prevention and treatment of various diseases in livestock and pets.

Upstream product

• 13312-83-9 4-chloromandelonitrile 
• 140-53-4 p-chlorobenzyl cyanide 

Downstream Products

• 1391013-18-5 N-(3-allyl-4-amino-5-(4-chloro-phenyl)-3H-thiazol-2-ylidine)-4-methyl-benzamide 
• 1391013-17-4 N-(4-amino-5-(4-chloro-phenyl)-3-phenyl-3H-thiazol-2-ylidine)-benzamide 
• 1391013-16-3 N-(4-amino-3,5-bis-(4-chloro-phenyl)-3H-thiazol-2-ylidine)-benzamine 
• 1351802-91-9 2,5-bis(4-chlorophenyl)-1,3-thiazol-4-amine 
• 1351802-90-8 5-(4-chlorophenyl)-2-phenyl-1,3-thiazol-4-amine 
• 50872-42-9 (3-trifluoromethylphenoxy)-(4-chlorophenyl)acetonitrile 
• 88875-62-1 2-[2-(4-Chloro-phenyl)-2-phenyl-acetoxy]-benzoic acid 2,2,2-trichloro-ethyl ester 
• 88875-70-1 2-[2-(4-Chloro-phenyl)-2-phenyl-acetoxy]-benzoic acid 
• 21771-88-0 α-(4-chlorophenyl)phenylacetic acid 
• 174574-63-1 C₁₈H₁₃Cl₂N₃O₄ 
• 219487-89-5 C₂₅H₂₀Cl₂N₄O₃ 
• 219487-67-9 N-Benzyl-N-[(4-chloro-phenyl)-cyano-methyl]-2-nitro-benzamide 
• 219487-76-0 2-Amino-N-benzyl-N-[(4-chloro-phenyl)-cyano-methyl]-benzamide 
• 324008-33-5 2-(2-{2-[(4-chloro-phenyl)-phenyl-methyl]-thiazol-4-yl}-ethyl)-isoindole-1,3-dione 

Relevant articles and documents

Enantioselective Mannich-Type Reactions to Construct Trifluoromethylthio-Containing Tetrasubstituted Carbon Stereocenters via Asymmetric Dual-Reagent Catalysis

An approach to construct tetrasubstituted carbon stereocenters bearing both a trifluoromethylthio (SCF3) group and a cyano group has been realized, through asymmetric organophosphine-catalyzed Mannich-type reactions. The products were obtained

An unexpected result of the reaction of benzothioamide derivatives with 2-aryl-2-bromoacetonitriles

Unexpectedly, in the reaction of 2-bromo-2-phenylacetonitrile derivatives with 2 mol-equiv. of benzothioamide in DMSO, 3,5-diaryl-1,2,4-thiadiazoles were obtained in excellent yields (83-90%) and in short reaction times (5-10 min). It is found that, in DMF, a quite different reaction takes place and 2,5-diaryl-1,3-thiazol-4-amines are formed as the main products. Copyright

PHARMACEUTICAL COMPOUNDS

Compounds of the formula (I), and salts, solvates, tautomers and N-oxide thereof; wherein TG is selected from groups (1) and (2): wherein the asterisk (*) represents the point of attachment of the group E to the group X; Rla is an optionally substituted aryl or heteroaryl group; Rlb is hydrogen or a group Rla; X is an optionally substituted bicyclic heterocyclic group having 8 to 12 ring members of which up to 5 are heteroatoms selected from O, N and S; and A, E, R2, R3, R4, Q1 and Q2 are as defined in the claims; provided that when E is aryl or heteroaryl, then Q2 is other than a bond; and further provided that the moiety (a) is other than a group (BG1) or (BG2); wherein (BGl) and (BG2) are each optionally substituted; T is N or CRZ; J1-J2 is selected from N=C(RZ), (RZ)C=N, (RZ)N-C(O), (RZ)2C-C(O), N=N and (RZ)C=C(R6); J4 -J3 is a group N=C(RZ) or a group (RZ)N-CO; and RZ is hydrogen or a substituent. The compounds of the formula (I) have PKA and PKB kinase inhibiting activity and are useful in the treatment of cancers.

Histamine H1 receptor ligands - Part II. Synthesis and in vitro pharmacology of 2-[2-(phenylamino)thiazol-4-yl]ethanamine and 2-(2-benzhydrylthiazol-4-yl)ethanamine derivatives

New 2-[2-(phenylamino)thiazol-4-yl]ethanamine and 2-(2-benzhydrylthiazol-4-yl)ethanamine derivatives were prepared and tested in vitro as H1 receptor antagonists. The compounds with 2-phenylamino substitution with meta-halide substituents at the phenyl ring, showed weak H1-antagonistic activity (pA2: 4.62-5.04) and this activity was completely lost in the case of meta-methyl substituent (pA2 : 4). When the phenylamino group was replaced by benzhydryl groups of classic antihistamines, the resulting compounds exhibited slightly improved H1-antagonistic activity (at the meta-position pA2: 6.38-6.15; at the para-position pA2: 6.04-5.87).

A synthetic route to [1,2,4]triazolo[1,5-a][4,1]benzoxazepines

A reaction sequence leading to the new title compounds is described, the key step of which is an intramolecular cycloaddition of nitrilimine to a nitrile group.

Preparation of (3-trifluoromethylphenoxy)(4-chlorophenyl)acetonitrile

A method for preparing 2-acetamidoethyl (3-trifluoromethylphenoxy)(4-chlorophenyl)acetate which comprises treating (3-trifluoromethylphenoxy)(4-chlorophenyl)acetonitrile with 2-acetamidoethanol in the presence of an acid to form an imino intermediate whic