- An improved and efficient process for the preparation of (+)-cloprostenol
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Abstract An improved and efficient synthesis of (+)-cloprostenol has been accomplished in nine steps and 26% overall yield from commercially available (-)-Corey lactone 4-phenylbenzoate alcohol 1. The present route avoids tedious purifications and require
- Chen, Yi,Yan, Hui,Chen, Hui-Xuan,Weng, Jiang,Lu, Gui
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p. 392 - 396
(2015/06/02)
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- PROSTANOIDS. XXVII. SOME ASPECTS OF CHEMO- AND STEREOSELECTIVE REDUCTION OF 7α-HYDROXY-6β-(3-OXO-4-m-CHLOROPHENOXY-1E-BUTENYL)-2-OXABICYCLOOCTAN-3-ONE
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The chemoselective reduction of 7α-hydroxy-6β-(3-oxo-4-m-chlorophenoxy-1E-butenyl)-2-oxabicyclooctan-3-one with respect to the oxo group was studied by means of readily obtainable reagents based on boron and aluminum.The optimum stereoselectivity of reduction was obtained with the use of diisobutylaluminum 2,6-di-tert-butyl-4-methylphenoxide in methylene chloride at -78 deg C.
- Miftakhov, M. S.,Vostrikov, N. S.,Kuznetsov, O. M.,Singizova, V. R.,Kuchin, A. V.,Tolstikov, G. A.
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p. 851 - 856
(2007/10/02)
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- N-(Methanesulfonyl)-16-phenoxyprostaglandincarboxamides: Tissue-Selective, Uterine Stimulants
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In an effort to develop tissue-selective prostaglandin analogues resistant to the metabolic inactivating pathways of the natural materials, hybrid compounds modified both at C-1 with a sulfonimide moiety and in the n-amylcarbinol side chain with substituted phenoxy groups were synthesized and evaluated in a variety of in vitro and in vivo models.Several of these analogues exhibited potent, tissue-selective, uterine stimulant activity, a finding subsequently confirmed in clinical studies with one member of this series, N-(methanesulfonyl)-16-phenoxy-ω-tetranor-PGE2-carboxamide (CP-34089/ZK-57671, sulprostone).
- Schaaf, Thomas K.,Bindra, Jasjit S.,Eggler, James F.,Plattner, Jacob J.,Nelson, A. James,et al.
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p. 1353 - 1359
(2007/10/02)
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