- ETHANEDIAMINE-HETEROCYCLE DERIVATIVES AS INHIBITORS OF PROTEIN ARGININE METHYLTRANSFERASES
-
The present invention relates to ethanediamine-heterocycle compounds that are able to act as inhibitors of PRMTs (protein arginine methyltransferases) for treating cancer and other diseases mediated by PRMTs.
- -
-
Paragraph 0763-0764
(2019/09/15)
-
- ARYL ANNULATED MACROCYCLIC INDOLE DERIVATIVES
-
The present invention relates to aryl annulated macrocyclic indole derivatives of general formula (I): in which R1, R2, R3, R4, R5, R6, A and L are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.
- -
-
Page/Page column 226
(2019/06/05)
-
- COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR
-
Compounds of Formula (I) or a pharmaceutically acceptable salt, a solvate, a tautomer, an isomer or a deuterated analog thereof, wherein A, J, R1, R2, R3, R4, R5, R6, R7, R9, X, m and n are as described herein, compositions thereof, and methods and uses thereof.
- -
-
Paragraph 0411
(2017/02/24)
-
- Reaction of arynes with vinylogous amides: Nucleophilic addition to the ortho-quinodimethide intermediate
-
The reaction of arynes with vinylogous amides containing no free N-H bonds proceeds in a [2 + 2] cycloaddition fashion at ambient temperature. The electronic properties of the vinylogous amides allow for the cycloadducts undergoing a facile ring-opening p
- Li, Ran,Wang, Xuemei,Wei, Zhibin,Wu, Chunrui,Shi, Feng
-
supporting information
p. 4366 - 4369
(2013/09/24)
-