- Dendritic Oligoglycerol Regioisomer Mixtures and Their Utility for Membrane Protein Research
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Dendrons are an important class of macromolecules that can be used for a broad range of applications. Recent studies have indicated that mixtures of oligoglycerol detergent (OGD) regioisomers are superior to individual regioisomers for protein extraction. The origin of this phenomenon remains puzzling. Here we discuss the synthesis and characterization of dendritic oligoglycerol regioisomer mixtures and their implementation into detergents. We provide experimental benchmarks to support quality control after synthesis and investigate the unusual utility of OGD regioisomer mixtures for extracting large protein quantities from biological membranes. We anticipate that our findings will enable the development of mixed detergent platforms in the future.
- Urner, Leonhard H.,Goltsche, Katharina,Selent, Marleen,Liko, Idlir,Schweder, Marc-Philip,Robinson, Carol V.,Pagel, Kevin,Haag, Rainer
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supporting information
p. 2537 - 2542
(2020/12/30)
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- METHOD FOR PRODUCING 2-HYDRAZINOBENZOTHIAZOLE DERIVATIVE
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The present invention provides a novel method for producing a 2-hydrazinobenzothiazole derivative. The present invention also provides a method for producing a compound by using the 2-hydrazinobenzothiazole derivative obtained by the production method, and a composition that contains the compound. The present invention also provides a polymerizable composition that is useful in producing film-shaped polymers and contains the compound obtained by the production method. The invention of the present application provides a method for producing a compound represented by general formula (I-C), the method including a step of reacting a compound represented by general formula (I-B) with a compound represented by general formula (I-A) in the presence of at least one compound selected from the group consisting of metal amides, metal hydrides, metal alkoxides, and organic alkali metals. A compound derived from the compound produced by the production method, and a composition that contains the compound are also provided.
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- POLYMERIZABLE CINNAMATE ESTER DERIVATIVE MANUFACTURING METHOD
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PROBLEM TO BE SOLVED: To provide a method of manufacturing a polymerizable cinnamate ester derivative that can be added to a liquid crystal composition in producing a TFT liquid crystal display element so as to reduce burning in the display element; a method of manufacturing a polymerizable composition containing the polymerizable cinnamate ester derivative; and a method of manufacturing a liquid crystal display element by polymerizing the polymerizable composition. SOLUTION: A method of manufacturing a compound represented by the specified general formula (III) includes reacting a compound represented by the specified general formula (I) with a compound represented by the specified general formula (II). SELECTED DRAWING: None COPYRIGHT: (C)2020,JPOandINPIT
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- Method for producing 2-hydrazinobenzothiazole derivative also providing a polymerizable composition which is useful for producing a film-like polymer
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The present invention provides a novel method for producing a 2-hydrazinobenzothiazole derivative. The present invention also provides a method for producing a compound using the 2-hydrazinobenzothiazole derivative obtained by the production method, and a composition containing the compound. The present invention also provides a polymerizable composition which is useful for producing a film-like polymer and contains the compound obtained by the production method. The present invention provides a method for producing a compound represented by general formula (I-C), which comprises a step for reacting a compound represented by general formula (I-B) and a compound represented by general formula (I-A) in the presence of at least one compound selected from the group consisting of metal amides, metal hydrides, metal alkoxides and organic alkali metals; the present invention also relates to a compound derived from the compound produced by the production method and a composition containing the compound.
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- POLYMERIZABLE COMPOUND AND OPTICALLY ANISOTROPIC BODY
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PROBLEM TO BE SOLVED: To provide a polymerizable compound which has high storage stability and can form a film-like polymer while being difficult to cause alignment defects, where the film-like polymer is less likely to be separated from a substrate even when irradiated with ultraviolet for a long time. SOLUTION: The invention provides a compound represented by general formula (I), and a polymer thereof. A composition comprising the compound is useful as a polymerizable liquid crystal composition. (For example, the compound is bis[4-(acryloyloxyethoxy-ethoxy-ethoxy)phenyl]1,4-cyclohexanedicarboxylate.) SELECTED DRAWING: None COPYRIGHT: (C)2018,JPOandINPIT
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- METHOD FOR PRODUCING POLYMERIZABLE COMPOUND
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The polymerizable compound has a hydrazone moiety. The present invention also provides a polymerizable composition in which discoloration and reduction of aligning property do not easily occur. Furthermore, the present invention provides a polymer obtained by polymerizing a polymerizable composition containing a compound obtained by the production method and an optically anisotropic body using the polymer. The present invention provides a method for producing a polymerizable compound including a step of reacting a compound represented by General Formula (I-B-a) with a compound represented by General Formula (I-B-b) to obtain a compound represented by General Formula (I-C), and provides a composition which contains a compound obtained by this production method.
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- POLYMERIZABLE COMPOUND, COMPOSITION, POLYMER, OPTICALLY ANISOTROPIC BODY, LIQUID CRYSTAL DISPLAY ELEMENT, AND ORGANIC EL DEVICE
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It is an object of the present invention to provide a polymerizable compound having a good liquid crystal property, a good alignment property, sufficient solubility in solvents, high preservation stability in a solution state, and high optical stability; a composition including the polymerizable compound; a polymer produced by polymerizing the polymerizable compound, such as a resin produced using the polymerizable compound; an optically anisotropic body including the polymer; and a liquid crystal display element and an organic EL device that include the optically anisotropic body. As a result of conducting intensive studies in order to achieve the above object, the compound represented by General Formula (I) is developed.
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- Polymerizable compound, a liquid crystal display element and polymerizable composition
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PROBLEM TO BE SOLVED: To provide a polymerizable compound having proper polymerization reactivity, high conversion rate and high solubility to a liquid crystal composition, a polymerizable composition containing the compound, a liquid crystal composite prepared from the composition and a liquid crystal display element having the composite.SOLUTION: There is provided a polymerizable compound having the following structure: (in the formula, Pand Pare a polymerizable group; rings Ato Aare 1,4-phenylene, Zand Zare a single bond or alkylene; Lto Lare a single bond; and a, b, c and d are 0 or 1.)
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Paragraph 0149; 0154
(2017/01/31)
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- P4VPy–CuO nanoparticles as a novel and reusable catalyst: application at the protection of alcohols, phenols and amines
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P4VPy–CuO nanoparticles were synthesized using ultrasound irradiations. Relevant properties of the synthesized nanoparticles were investigated by X-ray diffraction, scanning electron microscopy, transmission electron microscopy and Fourier transform infrared spectroscopy. After identification, the prepared reagent was used for the promotion of different types of protection reactions of alcohols, phenols and amines. Easy workup, short reaction times, excellent yields, relatively low cost and reusability of the catalyst are the striking features of the reported methods.
- Shirini, Farhad,Fallah-Shojaei, Abdollah,Abedini, Masoumeh,Samavi, Laleh
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p. 1699 - 1712
(2016/07/27)
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- Continuous-flow synthesis of functionalized phenols by aerobic oxidation of grignard reagents
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Phenols are important compounds in chemical industry. An economical and green approach to phenol preparation by the direct oxidation of aryl Grignard reagents using compressed air in continuous gas-liquid segmented flow systems is described. The process tolerates a broad range of functional groups, including oxidation-sensitive functionalities such as alkenes, amines, and thioethers. By integrating a benzyne-mediated in-line generation of arylmagnesium intermediates with the aerobic oxidation, a facile three-step, one-flow process, capable of preparing 2-functionalized phenols in a modular fashion, is established. Putting on airs: Aerobic oxidation of (hetero)aryl Grignard reagents using compressed air proceeds with a gas-liquid continuous-flow system, thus enabling preparation of fucntionalized phenols. By integrating an in-line generation of ArMgBr intermediates with the aerobic oxidation, ortho-functionalized phenols can be assembled. The method demonstrates good functional-group (FG) compatibility, mild reaction conditions, and short reaction times.
- He, Zhi,Jamison, Timothy F.
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supporting information
p. 3353 - 3357
(2014/04/03)
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- A catenane assembled through a single charge-assisted halogen bond
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Getting connected: The formation of pseudorotaxane assemblies between a designed macrocyclic halogen bonding (XB) acceptor (red in scheme) and a series of XB donor threading components was templated by a single halogen bond. The strength of the XB assembly between the pyridine macrocycle and iodopyridinium thread was utilized in the ring-closing metathesis clipping synthesis of a [2]catenane. Copyright
- Gilday, Lydia C.,Lang, Thomas,Caballero, Antonio,Costa, Paulo J.,Felix, Vitor,Beer, Paul D.
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supporting information
p. 4356 - 4360
(2013/05/22)
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- Chirality transfer from atropisomeric chiral inducers to nematic and smectic liquid crystals - Synthesis and characterization of di- and tetra-substituted axially chiral binaphthyl derivatives
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The chirality transfer of axially chiral binaphthyl derivatives bearing liquid crystal (LC) moieties at the n,n′ positions (n = 3, 4, 6) of the binaphthyl rings to nematic (N) and smectic (S) LCs is investigated. Chiral nematic LCs (N*-LCs) are prepared by adding a small amount of the chiral binaphthyl derivative into host N-LCs composed of cyanobiphenyl mesogen cores. The binaphthyl derivative with phenylcyclohexyl (PCH) type LC moieties at the 4,4′ positions of the binaphthyl ring [D-4,4′] exhibits a low helical twisting power (HTP) of 11 μm-1. In contrast, those with LC moieties at the 3,3′ and 6,6′ positions of the binaphthyl rings [D-3,3′ and D-6,6′] exhibit high HTPs of 153 μm-1 and 154 μm-1, respectively. Next, the binaphthyl derivatives are added into two types of S-LCs with phenylbenzoate mesogen cores: 4-(4- methylpentyloxy)phenyl-4-(decyloxy)benzoate [PhB1] and 4-(3-methylpentyloxy) phenyl-4-(decyloxy)benzoate [PhB2]. The mixture of the host LC, PhB1 or PhB2 with the chiral dopant, D-3,3′ or D-6,6′ shows chiral smectic LCs C (SC*-LCs). The highly twisted SC* phases with helical pitches of 1.2-1.4 μm are prepared in PhB1 and PhB2 by using the chiral dopant of D-6,6′. It is concluded that D-6,6′ has a large helical twisting power and is the most favourable atropisomeric chiral inducer for chirality transfer to both N-LCs and S-LCs.
- Goh, Munju,Park, Jinwoo,Han, Yehdong,Ahn, Sangbum,Akagi, Kazuo
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supporting information
p. 25011 - 25018
(2013/01/16)
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- MESOGEN CONTAINING COMPOUNDS
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Compounds including at least one mesogenic substructure and at least one long flexible segment and methods of synthesizing the same are disclosed. Formulations which include various embodiments of the mesogen containing compounds and their use in articles of manufacture and ophthalmic devices are also disclosed.
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Page/Page column 64
(2010/01/31)
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- DIOXETANE COMPOUND, CATIONICALLY POLYMERIZABLE COMPOSITION, OPTICAL FILM AND LIQUID CRYSTAL DISPLAY UNIT
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The present invention provides a novel dioxetane compound having a cationically polymerizable oxetane group, which compound is excellent in compatibility with a liquid crystalline compound and a non-liquid crystalline compound. The present invention also provides an optical film with excellent liquid crystal orientation retention properties and mechanical strength, produced by aligning a composition of the dioxetane compound and a cationically polymerizable compound in a liquid crystal orientation and fixing the liquid crystal orientation by polymerization, and a liquid crystal display device with the optical film.
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Page/Page column 13-14; 16-17
(2008/12/08)
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- Ruthenium(III) acetylacetonate [Ru(acac)3] - An efficient chemoselective catalyst for the tetrahydropyranylation (THP) of alcohols and phenols under solvent-free conditions
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A catalytic amount of ruthenium(III) acetylacetonate (2 mol%) [Ru(acac)3] enables solvent-free tetrahydropyranylation of different types of alcohols and phenols at ambient temperature in moderate to excellent yields. Notably, selective monoprotection of diols can be achieved chemoselectively. Furthermore, the catalyst could be recovered and reused if necessary.
- Varala, Ravi,Adapa, Srinivas R.
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p. 1174 - 1179
(2007/10/03)
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- SYNTHESIS OF HYDROQUINONE DERIVATIVES
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A method for synthesising a compound having the general formula (I) wherein R represents substituents selected independently from the group of H, F, Cl, Br, NO2, alkyl, aryl, aralkyl, alkoxy, aryloxy, aralkoxy and disubstituted amine R' is independently selected from the group of H, F, Cl, Br, OH, NO2, alkyl, aryl, aralkyl, alkoxy, aryloxy, aralkoxy and disubstituted amine, n is selected from 1, 2 or 3.
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Page/Page column 7
(2008/06/13)
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- Convenient tetrahydropyranylation of alcohols and phenols by catalytic ferric sulfate hydrate (Fe2(SO4)3· xH2O)
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Ferric sulfate hydrate (Fe2(SO4)3· xH2O) is found to be an efficient heterogeneous catalyst for the tetrahydropyranylation of alcohols and phenols at ambient or near ambient temperature. In addition, selective monotetrahydropyranylation of symmetrical diols is achieved under similar conditions. The deprotection of THP ether and direct transformation of THP ether to the corresponding acetate by Fe 2(SO4)3·xH2O is also studied. The simplicity of manipulation, mild conditions, reusable catalyst, good selectivity, and environment benign characters make this method a good alternative way for the THP protection of alcohols.
- Li, Lingjun,Zhu, Lizhi,Zhang, Xinying,Zhang, Guisheng,Qu, Guirong
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p. 1120 - 1123
(2007/10/03)
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- Strategies for the synthesis of bi- and triarylic materials starting from commercially available phenols
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A series of arylstannanes have been synthesized, through an SRN1 mechanism, in good to excellent yields (74%-99%) by the photostimulated reaction of trimethyl stannyl ion with substrates supporting different nucleofugal groups. The arylstannanes thus obtained were suitable intermediates for Stille cross-coupling reactions leading to asymmetric bi- and triaryl compounds in acceptable global yields. An attractive feature of this route is that simple commercially available benzenediols, chloro- and methoxy phenols might be useful starting substrates, leading the latter to higher global yields of products in fewer steps. The strategies proposed open a broad synthetic tool.
- Chopa, Alicia B.,Silbestri, Gustavo F.,Lockhart, María T.
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p. 3865 - 3877
(2007/10/03)
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- (Meth)acrylic compound having an oxetanyl group and liquid crystal film produced by using the same
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The present invention provides a novel compound which is suitable as the starting material of a side-chain type liquid crystalline polymeric substance having a reactive group which is excellent in reactivity upon fixation of the liquid crystal orientation structure. The novel compound is a (meth)acrylic compound having an oxetanyl group represented by the formula wherein R1 is hydrogen or methyl, R2 is hydrogen, methyl, or ethyl, "-L1-M-L2-" represents a mesogen portion, and n and m are each an integer of 0 to 10. The present invention also provides a liquid crystal film containing the side-chain type liquid crystalline polymeric substance and a liquid crystal display mounted with such a liquid crystal film.
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Page 8; 13-14
(2010/02/06)
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- Facile and selective deprotection of aryl acetates using sodium perborate under mild and neutral conditions
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A variety of aryl acetates are cleaved to the corresponding phenols using sodium perborate in methanol under mild conditions (25°C). The effectiveness of this protocol is manifested in its tolerance of different functional groups and selectivity of deprotection towards aryl acetates whereas alkyl acetates are found to be unreactive under these reaction conditions.
- Bandgar, Babasaheb P.,Uppalla, Lavkumar S.,Sadavarte, Vaibhav S.,Patil, Suresh V.
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p. 1273 - 1276
(2007/10/03)
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- Composition based on N-cholesteryloxycarbonyl-4-para-aminophenol and hydroquinone or one of its derivatives
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Compositions comprising, in a physiologically acceptable medium, N-cholesteryloxycarbonyl-4-para-aminophenol and hydroquinone or one of its derivatives may be used for depigmenting and/or lightening the skin, the body hair, and/or the head hair by applying such a composition to the skin, the body hair, and/or the head hair.
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