- Derivatives of (R)-3-(5-Furanyl)carboxamido-2-aminopropanoic Acid as Potent NMDA Receptor Glycine Site Agonists with GluN2 Subunit-Specific Activity
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NMDA receptors mediate glutamatergic neurotransmission and are therapeutic targets due to their involvement in a variety of psychiatric and neurological disorders. Here, we describe the design and synthesis of a series of (R)-3-(5-furanyl)carboxamido-2-am
- Zhao, Fabao,Atxabal, Unai,Mariottini, Sofia,Yi, Feng,Lotti, James S.,Rouzbeh, Nirvan,Liu, Na,Bunch, Lennart,Hansen, Kasper B.,Clausen, Rasmus P.
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p. 734 - 746
(2022/01/03)
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- Synthesis and SAR of 5-aryl-furan-2-carboxamide derivatives as potent urotensin-II receptor antagonists
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The synthesis and biological evaluation as potential urotensin-II receptor antagonists of a series of 5-arylfuran-2-carboxamide derivatives 1, bearing a 4-(3-chloro-4-(piperidin-4-yloxy)benzyl)piperazin-1-yl group, are described. The results of a systemat
- Lim, Chae Jo,Kim, Nam Hui,Park, Hye Jin,Lee, Byung Ho,Oh, Kwang-Seok,Yi, Kyu Yang
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p. 577 - 580
(2019/01/05)
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- An efficient synthesis of N,N-Dialkyl-5-(chlorophenyl)-2-furancarbothioamides from 2-furoic acid
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An efficient synthesis of N,N-dialkyl-5-(chlorophenyl)-2-furancarbothioamides from 2-furoic acid was performed under mild conditions as inhibitor candidates of plant growth. 5-(Chlorophenyl)-2-furoic acids (3a-d) were prepared by treating 2-furoic acid wi
- Lee, Hee Ju,Lee, Jae In
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p. 457 - 461
(2016/12/14)
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- Synthesis of heterocycles from arylation products of unsaturated compounds: XVIII. 5-Arylfuran-2-carboxylic acids and their application in the synthesis of 1,2,4-thiadiazole, 1,3,4-oxadiazole, and [1,2,4]triazolo[3,4-b][1,3,4] thiadiazole derivatives
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Arylation of furan-2-carboxylic acid or its methyl ester with arenediazonium chlorides in the presence of copper(II) chloride gave the corresponding 5-arylfuran-2-carboxylic acids or methyl 5-arylfuran-2- carboxylates. 5-Arylfuran-2-carbonyl chlorides rea
- Gorak,Obushak,Matiichuk,Lytvyn
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experimental part
p. 541 - 550
(2009/08/17)
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- Synthesis of some thiadiazolotriazinone derivatives as possible antimicrobial agents
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A series of 7-substituted-3-t-butyl 4(H)-1,3,4-thiadiazolo(2,3-c)-1,2,4- triazine-4-one (3) have been synthesized by condensing 4-amino-6-t-butyl-3- mercapto-1,2,4-triazin-5(4H)-one (1) with substituted Arylfuroic acids (2) using POCl3 as a cyclizing agen
- Prasad, D. Jagadeesh,Karthikeyan,Karegoudar, Prakash B.,Poojary, Boja,Holla, B. Shivarama,Kumari, N. Suchetha
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p. 1083 - 1091
(2008/02/01)
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