5406-37-1

Basic information

• Product Name: 2-(4-chlorophenyl)-4-methyl-1,3-dioxolane
• Synonyms: 2-(4-chlorophenyl)-4-methyl-1,3-dioxolane
• CAS NO: 5406-37-1
• Molecular Formula: C₁₀H₁₁ClO₂
• Molecular Weight: 198.6461
• Mol File: 5406-37-1.mol

Chemical Properties

• Boiling Point: 274.5 °C at 760 mmHg
• Flash Point: 106.5 °C
• Appearance: /
• Density: 1.19 g/cm³
• Vapor Pressure: 0.00901mmHg at 25°C
• Refractive Index: 1.524
• CAS DataBase Reference: 2-(4-chlorophenyl)-4-methyl-1,3-dioxolane(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-chlorophenyl)-4-methyl-1,3-dioxolane(5406-37-1)
• EPA Substance Registry System: 2-(4-chlorophenyl)-4-methyl-1,3-dioxolane(5406-37-1)

Safety Data

• Hazardous Substances Data: 5406-37-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-(4-chlorophenyl)-4-methyl-1,3-dioxolane is used as an intermediate in the synthesis of various pharmaceutical compounds for [application reason]. Its unique structure and functional groups make it a valuable building block in the development of new drugs with specific therapeutic properties.
Used in Agrochemical Industry:
2-(4-chlorophenyl)-4-methyl-1,3-dioxolane is used as a precursor in the production of agrochemicals for [application reason]. Its chemical properties allow it to be incorporated into the structures of various agrochemicals, potentially enhancing their effectiveness in pest control and crop protection.
Used in Organic Synthesis:
2-(4-chlorophenyl)-4-methyl-1,3-dioxolane is used as a versatile building block in organic synthesis for [application reason]. Its reactivity and compatibility with various chemical reactions make it suitable for the preparation of a wide range of organic compounds, including fine chemicals, specialty chemicals, and other industrial products.
(Note: The specific application reasons for each industry are not provided in the materials. They should be filled in based on the actual properties and potential uses of the compound after further research and testing.)

InChI:InChI=1/C10H11ClO2/c1-7-6-12-10(13-7)8-2-4-9(11)5-3-8/h2-5,7,10H,6H2,1H3

Upstream product

• 57-55-6 propylene glycol 
• 104-88-1 4-chlorobenzaldehyde 

Relevant articles and documents

Ni-NiO heterojunctions: a versatile nanocatalyst for regioselective halogenation and oxidative esterification of aromatics

Herein, we report a facile method for the synthesis of Ni-NiO heterojunction nanoparticles, which we utilized for the nuclear halogenation reaction of phenol and substituted phenols usingN-bromosuccinimide (NBS). A remarkablepara-selectivity was achieved for the halogenated products under semi-aqueous conditions. Interestingly, blocking of thepara-position of phenol offeredortho-selective halogenation. In addition, the Ni-NiO nanoparticles catalyzed the oxidative esterification of carbonyl compounds with alcohol, diol or dithiol in the presence of a catalytic amount of NBS. It was observed that the aromatic carbonyls substituted with an electron-donating group favoured nuclear halogenation, whereas an electron-withdrawing group substitution in carbonyl compounds facilitated the oxidation reaction. In addition, the catalyst was magnetically separated and recycled 10 times. The tuned electronic structure at the Ni-NiO heterojunction controlled selectivity and activity as no suchpara-selectivity was observed with commercially available NiO or Ni nanoparticles.

8-Hydroxy-2-methylquinoline-modified H4SiW12O40: A reusable heterogeneous catalyst for acetal/ketal formation

A heteropoly acid based organic hybrid heterogeneous catalyst, HMQ-STW, was prepared by combining 8-hydroxy-2-methylquinoline (HMQ) with Keggin-structured H4SiW12O40 (STW). The catalyst was characterized via elemental analysis, X-ray diffractometry (XRD), Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), thermogravimetric analysis (TG) and potentiometric titration analysis. The catalytic performance of the catalyst was assessed in the ketalization of ketones with glycol or 1,2-propylene glycol. Various reaction parameters, such as the glycol to cyclohexanone molar ratio, catalyst dosage, reaction temperature and time, were systematically examined. HMQ-STW exhibited a relatively high yield of corresponding ketal, with 100% selectivity under the optimized reaction conditions. Moreover, catalytic recycling tests demonstrated that the heterogeneous catalyst exhibited high potential for reusability, and it was revealed that the organic modifier HMQ plays an important role in the formation of a heterogeneous system and the improvement of structural stability. These results indicated that the HMQ-STW catalyst is a promising new type of heterogeneous acid catalyst for the ketalization of ketones.

Non-acid catalytic acetalisation of aldehydes with diols in ionic liquids

The acetalisation of aldehydes with diols to corresponding 1,3-dioxolanes has been accomplished using ionic liquids as catalyst and reaction media. In the reaction process the removal of water produced and other catalysts were not necessary. High conversion and good selectivity were obtained when using HMImBF4, which could be easily recycled and reused.

Acetals by AlFe-pillared montmorillonite catalysis

AlFe-pillared montmorillonite is an efficient catalyst for acetals preparation in CH2Cl2 at room temperature.