- Macrocyclic MCL-1 inhibitors and methods of use
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The present disclosure provides for compounds of Formula (I) wherein A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents for the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of Formula (I).
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Paragraph 0778
(2019/02/28)
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- Rapid microwave-assisted synthesis of phenyl ethers under mildly basic and nonaqueous conditions
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Microwave-assisted alkylation of phenols can be achieved within short reaction times under mild conditions using K2CO3 as a base, in methanol as a solvent. The method is suitable for base sensitive compounds or partially water-solubl
- Sarju, Julien,Danks, Timothy N.,Wagner, Gabriele
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p. 7675 - 7677
(2007/10/03)
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