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54080-21-6

Ethylenedioxy Spiperone is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 54080-21-6 Structure

  • Basic information

    1. Product Name: Ethylenedioxy Spiperone
    2. Synonyms: 8-[3-[2-(4-Fluorophenyl)-1,3-dioxolan-2-yl]propyl]-1-phenyl- 1,3,8-triazaspiro[4.5]decan-4-one;Ethylenedioxy Spiperone;1,3,8-Triazaspiro(4.5)decan-4-one, 8-(3-(2-(p-fluorophenyl)-1,3-dioxolan-2-yl)propyl)-1-phenyl-;8-(3-(2-p-Fluorophenyl-2-dioxolanyl)propyl)-4-oxo-1-phenyl-1,3,8-triazaspiro(4.5)decane;Brn 0634001
    3. CAS NO:54080-21-6
    4. Molecular Formula: C25H30FN3O3
    5. Molecular Weight: 439.52
    6. EINECS: N/A
    7. Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals
    8. Mol File: 54080-21-6.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 628.3°Cat760mmHg
    3. Flash Point: 333.8°C
    4. Appearance: /
    5. Density: 1.29g/cm3
    6. Vapor Pressure: 1.07E-15mmHg at 25°C
    7. Refractive Index: 1.627
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. CAS DataBase Reference: Ethylenedioxy Spiperone(CAS DataBase Reference)
    11. NIST Chemistry Reference: Ethylenedioxy Spiperone(54080-21-6)
    12. EPA Substance Registry System: Ethylenedioxy Spiperone(54080-21-6)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 54080-21-6(Hazardous Substances Data)

54080-21-6 Usage

Chemical Properties

Off-White Solid

Check Digit Verification of cas no

The CAS Registry Mumber 54080-21-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,4,0,8 and 0 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 54080-21:
(7*5)+(6*4)+(5*0)+(4*8)+(3*0)+(2*2)+(1*1)=96
96 % 10 = 6
So 54080-21-6 is a valid CAS Registry Number.
InChI:InChI=1/C25H30FN3O3/c26-21-9-7-20(8-10-21)25(31-17-18-32-25)11-4-14-28-15-12-24(13-16-28)23(30)27-19-29(24)22-5-2-1-3-6-22/h1-3,5-10H,4,11-19H2,(H,27,30)

54080-21-6Relevant articles and documents

Binding of spiperone analogs at 5-HT(2A) serotonin receptors

Khorana, Nantaka,Bondarev, Mikhail,Dukat, Malgorzata,Herrick-Davis, Katharine,Egan, Christina,DuPre, Ann,Smith, Carol,Teitler, Milt,Glennon, Richard A.

, p. 657 - 667 (2007/10/03)

Although spiperone displays good selectivity for 5-HT(2A) versus 5- HT(2C) serotonin receptors, it suffers from high affinity for 5-HT(1A) and dopamine D2 receptors. In order to determine a) the contribution of various structural features to 5-HT(2A) affinity, and b) if spiperone binds in a manner comparable to that of the 5-HT2 antagonist ketanserin, several abbreviated analogs of spiperone were prepared and examined. Removal of the spiperone fluoro group enhances 5-HT(2A) affinity several-fold, but does not improve its selectivity. The butyrophenone carbonyl group is not a major contributor to binding, but removal of the triazaspirodecanone carbonyl group reduces affinity at all receptor populations by about 100-fold. For a series of spiperone analogs, a three- to four-atom chain seems optimal for 5-HT(2A) affinity. On the basis of the structure-activity findings, it is concluded that ketanserin and spiperone likely bind at 5-HT(2A) receptors in a dissimilar manner.

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