54152-47-5Relevant articles and documents
Benzodiazepine derivatives
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, (2008/06/13)
Compounds of Formula (I), and salts and prodrugs thereof, wherein R1 represents H, optionally substituted C1-6 alkyl or C3-7 cycloalkyl; R2 is NHR12 or (CH2)s R13 where 5 is 0, 1 or 2; R3 represents C1-6 alkyl, halo or NR6 R7 ; R4 and R5 are H, C1-12 alkyl optionally substituted by NR9 R9' or an azacyclic or azabicyclic group, optionally substituted C4-9 cycloalkyl, C4-9 cycloalkyl C1-4 alkyl, aryl, arylC1-6 alkyl or azacyclic or azabicyclic groups, or R4 and R5 together form the residue of an optionally substituted azacyclic or azabicyclic ring system; x is 0, 1, 2 or 3; R12 is optionally substituted phenyl or pyridyl; R13 represents a group (A) wherein R14 is H or C1-6 alkyl; R15 is H, C1-6 alkyl, halo or NR6 R7 ; and the dotted line is an optional covalent bond; are CCK and/or gastrin antagonists useful in therapy. STR1
Substituted 3-aminosyndone imines, a process for their preparation and their use
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, (2008/06/13)
Substituted 3-aminosydnone imines of the formula I STR1 and their pharmacologically acceptable acid addition salts, in which A denotes, for example, --CH2 --, R1 denotes hydrogen or the radical --COR5, R2, R3 denote alkyl having 1 to 4 C atoms, R5 denotes, for example, an aliphatic radical having 1 to 4 C atoms, and methods for preparing such compounds by cyclization of a compound of the formula II STR2 and if desired subsequent acylation. The invention also includes formulations containing effective amounts of such compounds, and methods for administering same to patients for the control and prophylaxis of cardiovascular disorders.