- Ring contraction of cyclobutanes and a novel cascade reaction: Application to synthesis of (±)-anthoplalone and (±)-lepidozene
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Two efficient and practical synthetic methodologies for the construction of small ring systems have been developed. The first method involves a novel rearrangement of cyclobutanes 10 and 14 leading to cyclopropanes 11 and 15 employing BF3·OEts
- Ihara,Taniguchi,Tokunaga,Fukumoto
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p. 8092 - 8100
(2007/10/02)
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- Medium-Ring Ketone Synthesis. Total Syntheses of (+/-)-Isocaryophyllene and (+/-)-Caryophyllene
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Total syntheses of (+/-)-isocaryophyllene and (+/-)-caryophyllene are reported.The key step involves a novel construction of the nine-membered ring in these natural products by a base-induced intramolecular acyl transfer reaction of 13-membered lactam sul
- Ohtsuka, Yasuo,Niitsuma, Setsuko,Tadokoro, Hajime,Hayashi, Toshio,Oishi, Takeshi
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p. 2326 - 2332
(2007/10/02)
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- 11,12-Secoprostaglandins
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This invention relates to 11,12-secoprostaglandins and processes for their manufacture. These compounds have prostaglandin-like biological activity and are particularly useful as renal vasodilators, for the treatment of hypertension, for the prevention of thrombus formation, in preventing gastric secretion, and as regulators of the immune response.
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