- X-ray and computational investigations of ethanoanthracenes: 9,10-dihydro-9,10-ethanoanthracene-12-carboxylic acid and 9,10-dihydro-9,10-ethanoanthracen-9-yl)-N-methylethanamine
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Two ethanoanthracenes 3 and 5 have been synthesized, crystalized and computationally investigated. The ethanoanthracene 3 and 5 were crystallized in a monoclinic system; P21/c, a = 6.1899 (2) ?, b = 35.4668 (11) ?, c = 11.7945 (3) ?, β = 103.071 (1)°, V 2522.23 (13) ?3, Z = 8 and ethanoanthracene 5 was crystallized in a monoclinic system; P21/c, a = 11.0125 (3) ?, b = 32.1735 (7) ?, c = 11.1222 (3) ?, β = 114.026 (1)°, V = 3599.29 (16) ?3, Z = 4. The Hirshfeld analysis was employed to identify the intermolecular interactions of ethanoanthracenes 3 and 5 crystals. The molecular packing of ethanoanthracene 3 depends on H…H (57.1-59.1%), H…C (19.2-22.7%) and O…H (15.6–15.8%) contacts in addition to minor contributions from the C…O (1.1–2.5%) and C…C (2.1–4.7%) contacts, while the H…H (59.6–57.1%), H…C (21.2–22.7%) and Cl…H (15.6–17.1%) are the most important contacts in ethanoanthracene 5 molecular packing. The calculated dipole moments values for ethanoanthracene 3 (1.1452 Debye) are lower than ethanoanthracene 5 (8.8291 Debye). In addition, the atomic charge distribution, molecular electrostatic potential map and reactivity descriptors of the ethanoanthracenes 3 and 5 were reported.
- Al-Qubati, Mohyeddine,Alzahrani, Eman,Ghabbour, Hazem A.,Soliman, Saied M.,Sultan, Mujeeb A.
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- RESIST COMPOSITION AND METHOD OF FORMING RESIST PATTERN
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A resist composition including a compound represented by formula (bd1), a total amount of the acid-generator component and the basic component being 20 to 70 parts by weight, relative to 100 parts by weight of the base material component (wherein Rx1 to Rx4 represents a hydrogen atom or a hydrocarbon group, or two or more of Rx1 to Rx4 may be mutually bonded to form a ring structure; Ry1 and Ry2 represents a hydrogen atom or a hydrocarbon group, or Ry1 and Ry2 may be mutually bonded to form a ring structure; Rz1 to Rz4 represents a hydrogen atom or a hydrocarbon group, or two or more of Rz1 to Rz4 may be mutually bonded to form a ring structure; provided that at least one of Rx1 to Rx4 , Ry1 , Ry2 and Rz1 to Rz4 has an anionic group; and Mm+ represents an m-valent organic cation).
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Paragraph 0465-0467; 0548
(2020/07/28)
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- RESIST COMPOSITION, METHOD OF FORMING RESIST PATTERN, COMPOUND, AND ACID GENERATOR
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A resist composition containing a compound represented by the general formula (bd1-1), (bd1-2) or (bd1-3); in the formula, Rx1 to Rx4 represent a hydrocarbon group or a hydrogen atom or may be mutually bonded to form a ring structure; Ry1 to Ry2 represent a hydrocarbon group or a hydrogen atom or may be mutually bonded to form a ring structure, Rz1 to Rz4 represent a hydrocarbon group or a hydrogen atom or may be mutually bonded to form a ring structure. At least one of Rx1 to Rx4, Ry1 to Ry2 and Rz1 to Rz4 has an anion group, M1m+ represents a sulfonium cation having a sulfonyl group, R001 to R003 each independently represent a monovalent organic group; provided that at least one of R001 to R003 is an organic group having an acid dissociable group; and M3m+ represents an m-valent organic cation having an electron-withdrawing group.
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Paragraph 1148; 1262
(2019/12/06)
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- RESIST COMPOSITION, METHOD OF FORMING RESIST PATTERN, COMPOUND, AND ACID GENERATOR
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A resist composition including a base component which exhibits changed solubility in a developing solution under action of acid, and a compound (B1) having an anion moiety and a cation moiety and being represented by general formula (b1) (wherein R01 to R014 each independently represents a hydrogen atom or a hydrocarbon group which may have a substituent, or two or more of R01 to R014 may be mutually bonded to form a ring structure, provided that at least two of R01 to R014 are mutually bonded to form a ring structure, and at least one of R01 to R014 has an anion group, and the anion moiety as a whole forms an anion having a valency of n; n represents an integer of 1 or more; represents an integer of 1 or more; and Mm+ represents an organic cation having a valency of m).
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Paragraph 0710
(2018/06/09)
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- Synthesis and antiproliferative action of a novel series of maprotiline analogues
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The synthesis of a diverse library of compounds structurally related to maprotiline, a norepinephrine reuptake transporter (NET) selective antidepressant which has recently been identified as a novel in vitro antiproliferative agent against Burkitt's lymp
- McNamara,Bright,Byrne,Cloonan,McCabe,Williams,Meegan
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p. 333 - 353
(2014/01/06)
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- Synthesis of Precursors for the Pyrolytic Formation of Pentatetraenones
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3-(9',10'-Dihydro-9',10'-ethanoanthracen-11'-ylidene)prop-2-enoyl chloride and its [12',12'-2H2] and [1-13C] isotopomers have been prepared and pyrolysed. Argon matrix infrared spectroscopy showed ν2 bands at 2207.7, 2207.0, and 2168.5 cm-1 respectively for the three pentatetraenone isotopomers. The pyrolysate of the 12'-methyl substituted precursor showed a band at 2205 cm-1 which was tentatively assigned to methylpentatetraenone. The 12'-ethenyl substituted precursor gave a pyrolysate showing ketene bands but also yielded 9,10-dihydro-9,10[1',2']-benzenoanthracene.
- Arena, Phillip,Brown, Roger F. C.,Eastwood, Frank W.,McNaughton, Don
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p. 663 - 672
(2007/10/03)
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- Dihetero nitrogen-containing cycloheteroethanoanthracene derivatives as antipsychotic agents
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A class of ethanoanthracene derivatives is described having use in treatment of CNS disorders such as psychotic, convulsive and dystonic disorders. Compounds of particular interest are those of the formula wherein each of R5 and R6 is independently selected from hydrido, loweralkyl, benzyl and phenyl; wherein each of R7 through R11 is independently selected from hydrido, loweralkyl, hydroxy, benzyl, phenyl, loweralkoxy, phenoxy, benzyloxy, halo and haloloweralkyl; wherein R12 may be selected from hydrido, loweralkyl, cycloalkyl of five or six carbon atoms, cycloalkylalkyl of six or seven carbon atoms, phenyl, hydroxyloweralkyl, and heteroaryl selected from saturated or fully unsaturated heterocyclic rings containing five to seven ring members of which one or two ring members are nitrogen atom; wherein each Y is independently one or more groups selected from hydrido, hydroxy, loweralkyl, benzyl, phenyl, loweralkoxy, phenoxy, haloloweralkyl, halo, and loweralkanoyl; and wherein each of R13 through R20 is independently selected from hydrido, lower alkyl, benzyl, phenyl and halo; wherein R12 together with one of R13, R14, R19 or R20 may form a fused heterocyclic ring containing five or six ring members; or a pharmaceutically-acceptable salt thereof.
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- Use of bridged tricyclic amine derivatives as anti-ischemic agents
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Certain bridged tricyclic amine compounds are described as being therapeutically effective in treatments of CNS disorders resulting from neurotoxic damage or neurodegenerative diseases, particularly those CNS disorders resulting from ischemic events. Compounds of particular interest for use as neuroprotective agents are those of the formula STR1 wherein each of R1 and R2 is independently selected from hydrido, loweralkyl, benzyl and phenyl; wherein each of R1 through R7 is independently selected from hydrido, loweralkyl, hydroxy, benzyl, phenyl, loweralkoxy, phenoxy, benzyloxy, halo and haloloweralkyl; wherein R18 may be selected from hydrido, loweralkyl, cycloalkyl of five or six carbon atoms, cycloalkylalkyl of six or seven carbon atoms, phenyl, hydroxyloweralkyl, and heteroaryl selected from saturated or fully unsaturated heterocyclic rings containing five to seven ring members of which one or two ring members are nitrogen atom; wherein each X is independently one or more groups selected from hydrido, hydroxy, loweralkyl, benzyl, phenyl, loweralkoxy, phenoxy, haloloweralkyl, halo, and lower-alkanoyl; and wherein each of R23 through R30 is independently selected from hydrido, lower alkyl, benzyl, phenyl and halo; wherein R18 together with one of R23, R24, R29 or R30 may form a fused heterocyclic ring containing five or six ring members; or a pharmaceutically-acceptable salt thereof.
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- Structural Effects Controlling the Rate of the Retro-Diels-Alder Reaction in Anthracene Cycloadducts
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We have undertaken a fairly broad study of how the structure of an anthracene cycloadduct affects the rate of its cycloreversion reaction.Based on the rate constants for retro-Diels-Alder (rDA) reactions of a variety of anthracene-type adducts conducted in diphenyl ether, we draw the following conclusions.The rDA reaction of anthracene cycloadducts is influenced by diene substituents in the following ways: (1) electron-donating groups increase the reaction rate, and the accelerating effect is subject to geometric modulation for a conjugating substituent like dimethylamino; (2) electron-withdrawing groups may decrease or increase the reaction rate , although the effect is rarely large; and (3) steric acceleration is relatively small and demonstrates an unprecedented bell-shaped structure-reactivity profile.Peripheral substitution of the adduct with siloxy groups results in a significant acceleration, even though the groups are three bonds removed from the reaction site.The same reaction is influenced by dienophile substituents in the following ways: (1) electron-withdrawing groups increase the rate of the reaction; (2) strongly conjugating substituents make the reaction much faster than predicted by classical electron-withdrawing or -donating ability due to a change to polar mechanism; and (3) there is no observable steric effect.
- Chung, Yongseog,Duerr, Brook F.,McKelvey, Timothy A.,Nanjappan, P.,Czarnik, Anthony W.
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p. 1018 - 1032
(2007/10/02)
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