- METHOD FOR PREPARING LAMOTRIGINE AND ITS INTERMEDIATE 2,3-DICHLOROBENZOYL CHLORIDE
-
The invention relates to an improved method for preparing 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine, also commonly known as lamotrigine. The present invention also relates to a method for preparing the intermediate 2,3-dichlorobenzoyl chloride, which comprises the synthesis by photochlorination of 2,3-dichlorobenzotrichloride followed by hydrolysis thereof. Said 2,3-dichlorobenzoyl chloride intermediate is useful for preparing lamotrigine.
- -
-
Page/Page column 14
(2010/11/29)
-
- THERAPEUTIC USE OF ARYL AMINO ACID DERIVATIVES
-
The compounds of formula (I) are useful in the treatment of faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, neuropathic pain, neuropathological disorders and sleep disorders. Processes for the preparation of the final products and intermediates useful in the process are included. Pharmaceutical compositions containing one or more of the compounds are also included.
- -
-
Page/Page column 35-36
(2010/02/06)
-
- Electrochemistry of cyanocopper thiomolybdates and thiotungstates: Redox-based interconversion of species
-
[MoS4]2- and its 1:1 and 1:2 CuCN adducts [(CN)CuS2MoS2]2- and [(CN)CuS2MoS2Cu(CN)]2- each exhibit electrochemically reversible one-electron reductions in MeCN at fast scan rates (>500 mV s-1). At lower scan rates, the reduced adduct species are unstable to dissociation of CuCN, leading to interconversion of the three anions. The tungsten analogues show similar properties.
- Kony, Michael,Bond, Alan M.,Wedd, Anthony G.
-
p. 4521 - 4525
(2008/10/08)
-